Primary Information |
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BoMiProt ID | Bomi9050 |
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Protein Name | Serine/threonine-protein kinase PLK4/Polo-like kinase 4/Serine/threonine-protein kinase Sak |
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Organism | Bos taurus |
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Uniprot ID | A2VDZ4 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001076896.1 |
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Aminoacid Length | 893 |
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Molecular Weight | 100707 |
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FASTA Sequence |
Download |
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Gene Name | PLK4/SAK |
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Gene ID | 514405 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | role in centrosome duplication.When PLK4 is chemically inhibited, cell division proceeds without centrosome duplication, generating centrosome-less cells that exhibit delayed, acentrosomal spindle assembly. |
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PTMs | Ubl conjugation,Acetylation on Lys, Phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A2VDZ4|PLK4_BOVIN Serine/threonine-protein kinase PLK4 OS=Bos taurus OX=9913 GN=PLK4 PE=2 SV=1
MATCIGEKIEDFRVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE
VKIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRRKPFSENEARHFMHQI
ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLAAQLKMPHEKHYTLCGTPNYISP
EIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSREAKD
LIHQLLRRNPADRLSLSSVLDHPFMSRNSSKKSKDLGTVEDSIDSGHATISTAITASSST
SISGSLFDRRRLLIEQPLPNKMTIFPKNKNPSDFSSSGDGISFYTSWGNQEQETSNSGRG
RVIQEAEERPHSRYLRRAHSSDRSETSHGQSRVKTYTMERCYS*403AEMLSKSKRSGVEENER
YSPTNNDANIFHFFKEKTSNSSGSFEGPDNNQALSNHLCPGKTPFPFPEQTPQTEMVQQW
FGNLQINDPSCEQSKTRGVEPPLVYQKRTLRSITSPLTAYRLKPIRQKTKKAVVSILDSE
EVCVELLKDYASQEYVKEVLQISSDGSMITIYYPNDGRGFLLADRPPS*588PTDNISRYSFDN
LPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCVLMENSPGADFEVWFYDGAKIHKTE
DLIQVIEKTGRSYTLKGESEVNSLKEEVKMYMNHANEGHRICLALESIISEEEKKSGSAP
FFPIIVGRRPSSTSSPKALTPPPPVDPNYPMRETPSLNRMIINSAASPKQAPVLNPPVVT
NEGLGLMGAASETNSSPRSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQL
VVQAGVSSISYTSPDGQTTRYGENEKLPEYIKQKLQCLSSILLMFSNPTPSFH
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Predicted Disorder Regions | 330-337, 386-388, 416-426, 459-482, 734-802 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Ubl conjugation by TRIM37,a TRIpartite Motif ubiquitin ligase,which functions as a rheostat that controls cell division.Spata2 recruits the deubiquitinase CYLD to the centrosome for deubiquitination of polo-like kinase 4 (PLK4),which supresses inflammasome activation at the centrosome. |
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Bibliography | 1.Yang XD, Li W, Zhang S, Wu D, Jiang X, Tan R, Niu X, Wang Q, Wu X, Liu Z, Chen LF, Qin J, Su B. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J. 2020 Jan 15;39(2):e102201. doi: 10.15252/embj.2019102201. Epub 2019 Nov 25. PMID: 31762063; PMCID: PMC6960439. 2.Meitinger F, Ohta M, Lee KY, Watanabe S, Davis RL, Anzola JV, Kabeche R, Jenkins DA, Shiau AK, Desai A, Oegema K. TRIM37 controls cancer-specific vulnerability to PLK4 inhibition. Nature. 2020 Sep;585(7825):440-446. doi: 10.1038/s41586-020-2710-1. Epub 2020 Sep 9. PMID: 32908304; PMCID: PMC7501188. |