Search by BoMiProt ID - Bomi9028


Primary Information

BoMiProt ID Bomi9028
Protein Name Serine beta-lactamase-like protein LACTB, mitochondrial
Organism Bos taurus
Uniprot IdP83095
Milk FractionWhey
Aminoacid Length 556
Molecular Weight 61683
Fasta Sequence https://www.uniprot.org/uniprot/P83095.fasta
Gene Name LACTB
Protein Existence Status reviewed

Secondary Information

Protein Function mammalian active-site serine protein that has evolved from a bacterial penicillin-binding protein.polymerized into stable filaments with a length extending more than a hundred nanometers. through polymerization, promotes intramitochondrial membrane organization and micro-compartmentalization.mitochondrial protein LACTB potently inhibits the proliferation of breast cancer cells.
PTMs Acetylation,phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Lysine acetylation of LACTB occurs during starvation indicating that LACTB is modulated by acetyltransferases and deacetylase enzymes.The first serine residue located in the catalytic -SISKmotif of LACTB was phosphorylated under normal conditions suggesting that LACTB is activated by a specific phosphoprotein phosphatase.
Bibliography Polianskyte Z, Peitsaro N, Dapkunas A, Liobikas J, Soliymani R, Lalowski M, Speer O, Seitsonen J, Butcher S, Cereghetti GM, Linder MD, Merckel M, Thompson J, Eriksson O. LACTB is a filament-forming protein localized in mitochondria. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):18960-5. doi: 10.1073/pnas.0906734106. Epub 2009 Oct 26. PMID: 19858488; PMCID: PMC2767363.