Primary Information |
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| BoMiProt ID | Bomi8887 |
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| Protein Name | RNA polymerase II-associated factor 1 homolog |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KJ14 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039758.1 |
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| Aminoacid Length | 532 |
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| Molecular Weight | 60280 |
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| FASTA Sequence |
Download |
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| Gene Name | PAF1 |
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| Gene ID | 528744 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | role in transcrpition elongation. Pol II-associated factor 1 (PAF1) modulates the release of paused Pol II into productive elongation. |
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| PTMs | Phosphorylation,Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KJ14|PAF1_BOVIN RNA polymerase II-associated factor 1 homolog OS=Bos taurus OX=9913 GN=PAF1 PE=2 SV=1
MAPTIQTQAQREDGHRPNSHRTLPERSGVVCRVKYCNSLPDIPFDPKFITYPFDQNRFVQ
YKATSLEKQHKHDLLTEPDLGVTIDLINPDTYRIDPNVLLDPADEKLLEEEIQAPTS*117SKR
SQQHAKVVPWMRKTEYISTEFNRYGISNEKPEVKIGVSVKQQFTEEEIYKDRDSQITAIE
KTFEDAQKSISQHYSKPRVTPVEVMPVFPDFKMWINPCAQVIFDSDPAPKDTSGAAALEM
MSQAMIRGMMDEEGNQFVAYFLPVEETLKKRKRDQEEEMDYAPDDVYDYKIAREYNWNVK
NKASKGYEENYFFIFREGDGVYYNELETRVRLSKRRAKAGVQSGTNALLVVKHRDMNEKE
LEAQEARKAQLENHEPEEEEEEEMETEEKEAGASDEEREKGSSSEKEGSEDERSGSESER
EEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGS*456DADSEDDADSDDEDRGRARGSDND
SDSGSDGGGQRSRSHSRSRSASPFPSGSEHSAQEDGSEAAASDSSEADSDSD
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| Predicted Disorder Regions | 1-26, 111-125, 233-235, 335-532 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | CNOT4 may control the expression or activity of unidentified E3 ligases or deubiquitinases that target PAF1 for ubiquitination.PAF1 is poly-ubiquitinated and degraded via the 26S proteasome.CNOT4 plays a key role in the regulation of PAFc-mediated gene expression. |
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| Bibliography | Sun HY, Kim N, Hwang CS, Yoo JY. Protein Degradation of RNA Polymerase II-Association Factor 1(PAF1) Is Controlled by CNOT4 and 26S Proteasome. PLoS One. 2015 May 1;10(5):e0125599. doi: 10.1371/journal.pone.0125599. PMID: 25933433; PMCID: PMC4416890. |
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