Search by BoMiProt ID - Bomi8886


Primary Information

BoMiProt ID Bomi8886
Protein Name RNA polymerase II elongation factor ELL3
Organism Bos taurus
Uniprot IdF1MGG3
Milk FractionWhey
Ref Sequence Id NP_001039591.1
Aminoacid Length 395
Molecular Weight 44890
Fasta Sequence https://www.uniprot.org/uniprot/F1MGG3.fasta
Gene Name ELL3
Gene Id 512648
Protein Existence Status reviewed

Secondary Information

Protein Function Ell3, a member of the Ell (eleven-nineteen lysine-rich leukemia gene) family of RNA Pol II elongation factors, occupies enhancers in embryonic stem cells.
Biochemical Properties ELL3, a novel RNA polymerase II elongation factor approximately 50% similar to both ELL and ELL2.Ell3's association with enhancers is required for setting up proper Pol II occupancy at the promoter-proximal regions of developmentally regulated genes and for the recruitment of the super elongation complex (SEC) to these loci following differentiation signals.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-5, 121-303, 339-342
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments  ELL3 is a testis-specific RNA polymerase II elongation factor.
Bibliography 1.Lin C, Garruss AS, Luo Z, Guo F, Shilatifard A. The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation. Cell. 2013 Jan 17;152(1-2):144-56. doi: 10.1016/j.cell.2012.12.015. Epub 2012 Dec 27. PMID: 23273992; PMCID: PMC3556173. 2.Miller T, Williams K, Johnstone RW, Shilatifard A. Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3. J Biol Chem. 2000 Oct 13;275(41):32052-6. doi: 10.1074/jbc.M005175200. PMID: 10882741.