Search by BoMiProt ID - Bomi8823


Primary Information

BoMiProt ID Bomi8823
Protein Name RING finger protein 207
Organism Bos taurus
Uniprot IdA0JNG4
Milk FractionWhey
Ref Sequence Id NP_001071525.1
Aminoacid Length 556
Molecular Weight 61668
Fasta Sequence https://www.uniprot.org/uniprot/A0JNG4.fasta
Gene Name RNF207
Gene Id 616057
Protein Existence Status reviewed

Secondary Information

Protein Function  novel RING-finger protein 207 (RNF207), which is specifically expressed in the heart, plays a role in cardiac energy metabolism.Imp for cellular concentration of adenosine triphosphate (ATP) and mitochondrial function.RNF207 interacts with the voltage-dependent anion channel (VDAC), which is considered to be a key regulator of mitochondria function.
Biochemical Properties (RING)-finger domain contains eight metal-binding residues that coordinate two zinc atoms forinc motifs are called as B boxes.Region containing B-boxes and the coiled-coil is likely to be responsible for the interaction with substrates.RING-finger domain, which is known to be required for the activities of E3 ubiquitin ligases.
Linking IDs Bomi8823
Bibliography Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S. The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. J Mol Cell Cardiol. 2016 Nov;100:43-53. doi: 10.1016/j.yjmcc.2016.09.013. Epub 2016 Sep 25. PMID: 27677939.
Protein Function  novel RING-finger protein 207 (RNF207), which is specifically expressed in the heart, plays a role in cardiac energy metabolism.Imp for cellular concentration of adenosine triphosphate (ATP) and mitochondrial function.RNF207 interacts with the voltage-dependent anion channel (VDAC), which is considered to be a key regulator of mitochondria function.
Biochemical Properties (RING)-finger domain contains eight metal-binding residues that coordinate two zinc atoms forinc motifs are called as B boxes.Region containing B-boxes and the coiled-coil is likely to be responsible for the interaction with substrates.RING-finger domain, which is known to be required for the activities of E3 ubiquitin ligases.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 332-367, 523-556
DisProt Annotation
TM Helix Prediction no TM helices
Linking IDs
Bibliography Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S. The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. J Mol Cell Cardiol. 2016 Nov;100:43-53. doi: 10.1016/j.yjmcc.2016.09.013. Epub 2016 Sep 25. PMID: 27677939.