Search by BoMiProt ID - Bomi8816


Primary Information

BoMiProt ID Bomi8816
Protein Name RING finger protein 112/Zinc finger protein 179
Organism Bos taurus
Uniprot IdQ08DF2
Milk FractionWhey
Ref Sequence Id NP_001070607.1
Aminoacid Length 628
Molecular Weight 67392
Fasta Sequence https://www.uniprot.org/uniprot/Q08DF2.fasta
Gene Name RNF112/ZNF179
Protein Existence Status reviewed

Secondary Information

Protein Function E3-ubiquitin ligase.neuronal differentiation, including neurogenesis and gliogenesis.synthesis of NaV channels and subsequent transport to the membrane.
Significance in milk Neuroprotective
PTMs Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 4 disordered segments; (24-46),( 401-409), (437-444), (607-628)
DisProt Annotation
TM Helix Prediction 2TMHs; (550-572) and (579-601)
Bibliography Ogino K, Low SE, Yamada K, Saint-Amant L, Zhou W, Muto A, Asakawa K, Nakai J, Kawakami K, Kuwada JY, Hirata H. RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2859-64. doi: 10.1073/pnas.1414002112. Epub 2015 Feb 17. PMID: 25691753; PMCID: PMC4352840.