Primary Information |
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| BoMiProt ID | Bomi8816 |
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| Protein Name | RING finger protein 112/Zinc finger protein 179 |
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| Organism | Bos taurus |
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| Uniprot Id | Q08DF2 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_001070607.1 |
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| Aminoacid Length | 628 |
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| Molecular Weight | 67392 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/Q08DF2.fasta |
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| Gene Name | RNF112/ZNF179 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | E3-ubiquitin ligase.neuronal differentiation, including neurogenesis and gliogenesis.synthesis of NaV channels and subsequent transport to the membrane. |
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| Significance in milk | Neuroprotective |
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| PTMs | Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 4 disordered segments; (24-46),( 401-409), (437-444), (607-628) |
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| DisProt Annotation | |
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| TM Helix Prediction | 2TMHs; (550-572) and (579-601) |
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| Bibliography | Ogino K, Low SE, Yamada K, Saint-Amant L, Zhou W, Muto A, Asakawa K, Nakai J, Kawakami K, Kuwada JY, Hirata H. RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2859-64. doi: 10.1073/pnas.1414002112. Epub 2015 Feb 17. PMID: 25691753; PMCID: PMC4352840. |
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