Search by BoMiProt ID - Bomi8801


Primary Information

BoMiProt ID Bomi8801
Protein Name Ribosomal protein S6 kinase beta-1/S6K-beta-1/S6K1/70 kDa ribosomal protein S6 kinase 1/P70S6K1/p70-S6K 1
Organism Bos taurus
Uniprot IdQ6TJY3
Milk FractionWhey
Ref Sequence Id NP_991385.1
Aminoacid Length 527
Molecular Weight 59352
Fasta Sequence https://www.uniprot.org/uniprot/Q6TJY3.fasta
Gene Name RPS6KB1
Gene Id 404181
Protein Existence Status reviewed

Secondary Information

Protein Function Serine/threonine-protein kinase that acts downstream of mTOR signaling.Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD.
Significance in milk role in milk protein synthesis
PTMs phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q6TJY3|KS6B1_BOVIN Ribosomal protein S6 kinase beta-1 OS=Bos taurus OX=9913 GN=RPS6KB1 PE=2 SV=1 MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC KESIHDGTVTHT*252FCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDS*394PDDSALSESANQVFLGFT*412YVAPSVLE SVKEKFSFEPKIRS*434PRRFIGS*441PRT*444PVS*447PVKFS*452PGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNLEL
Predicted Disorder Regions 1-75, 388-400, 430-498, 503-526
DisProt Annotation
TM Helix Prediction no TM helices
Significance of PTMs phosphorylation-p70S6K1 protects myocardial cells from ischemic injury.Decreased p70S6K1 phosphorylation induces cell cycle arrest and apoptosis. mTOR phosplorylated at Ser2448; S6K1, p70 ribosomal protein S6 kinase-1; S6K1 (Thr389). The phosphorylation of S6K1 leads to the activation of several components of the protein translation apparatus in cells.
Bibliography 1.Li, H., Liu, X., Wang, Z., Lin, X., Yan, Z., Cao, Q., Zhao, M., & Shi, K. (2017). MEN1/Menin regulates milk protein synthesis through mTOR signaling in mammary epithelial cells. Scientific reports, 7(1), 5479. https://doi.org/10.1038/s41598-017-06054-w 2.Xie Q, Liu M, Yan YF, Shen X, Wang ES. Exogenous Tetranectin Protects Against 1-Methyl-4-Phenylpyridine-Induced Neurotoxicity by Inhibiting Apoptosis and Autophagy Through Ribosomal Protein S6 Kinase Beta-1. World Neurosurg. 2019 Feb;122:e375-e382. doi: 10.1016/j.wneu.2018.10.058. Epub 2018 Oct 18. PMID: 30342268.