Search by BoMiProt ID - Bomi8792


Primary Information

BoMiProt ID Bomi8792
Protein Name Ribosomal L1 domain-containing protein 1
Organism Bos taurus
Uniprot IdA4FV97
Milk FractionWhey
Aminoacid Length 482
Molecular Weight 53076
Fasta Sequence https://www.uniprot.org/uniprot/A4FV97.fasta
Gene Name RSL1D1
Protein Existence Status reviewed

Secondary Information

Protein Function a novel senescence-associated gene.Acts as pro-apoptotic regulator in response to DNA damage.participates in ribosome biosynthesis or acts as a transcriptional cofactor.Can regulate the activity of nucleostemin which delays the aging progression in mouse fibroblasts.RSL1D1 interacted with RAN and inhibited its deacetylation by competitively binding with Sirt7. By affecting the acetylation of RAN, RSL1D1 inhibited the accumulation of nuclear STAT3 and the STAT3-regulated autophagic program.
Biochemical Properties C-terminal (residues 317–452) is imp for binding to nucleostamin for age delaying process.contains part of the ribosomal L1p/L10e consensus sequence in its N-terminus and a long lysine-rich domain in its C-terminus,which is the target for CRC.
PTMs Acetylation,Phosphorylation,Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|A4FV97|RL1D1_BOVIN Ribosomal L1 domain-containing protein 1 OS=Bos taurus OX=9913 GN=RSL1D1 PE=2 SV=1 MEASASNPPSTSPETSASTPETPPGPEQLDEEQVKKAVEALLAHSRSRKNANGLLLNENE NFFLMVVLWKIPSKELRVRLSLPHGIRSDLADVCLFTKDEPNLSSEQTERYYKKLLNNHG IKTISQIIPFRTLKKEYKAYEAKLRLLGSFDFFITDARIRRLLPSHLGRHFYNRKKVPVS VNLQSKTLSREINDCIGGTVLNISKSGSCSTIRIGHTGMPIQHIVENVVAVAKSLSQKLP EKWESVKLLFVKTERSVSLPVFSSFVSSQGEAKGLRTRDLLKKVSKKSRKKTERALKRQQ EKKEKKLLKQAAKAKPAPTTDAVAPKTGGVPTQDPAPQEETGGVSALPKAQDDS*354EDEIPL LVPLKET*367PAAGSTKIQKAAIGKKS*384PKKS*388PGPNTARAKKRKASPALET*407PIAAEPKT*415PGKGPGKKARVKEEVEKERNSSLGKKDPRQTPKKPEAKFFTT*457ASSS*461VKKAPRTLTQRPKKPKVPQ ST
Predicted Disorder Regions 1-37, 47-52, 269-482
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs acetylated RSL1D1 protein interacts with Sirt7 and is deacetylated by Sirt7.
Bibliography 1.Liu X, Chen J, Long X, Lan J, Liu X, Zhou M, Zhang S, Zhou J. RSL1D1 promotes the progression of colorectal cancer through RAN-mediated autophagy suppression. Cell Death Dis. 2022 Jan 10;13(1):43. doi: 10.1038/s41419-021-04492-z. PMID: 35013134; PMCID: PMC8748816. 2.Ma L, Zhao W, Zheng Q, Chen T, Qi J, Li G, Tong T. Ribosomal L1 domain and lysine-rich region are essential for CSIG/ RSL1D1 to regulate proliferation and senescence. Biochem Biophys Res Commun. 2016 Jan 15;469(3):593-8. doi: 10.1016/j.bbrc.2015.12.004. Epub 2015 Dec 12. PMID: 26686419.