Biochemical Properties | RND1 shares 41% identity with RHOA protein, RND proteins differ from other Rho GTPases by several features. They contain an extension of 30 amino acids at the C-terminal and RND1 and RND3 proteins possess 8 and 18 additional amino acids, respectively, at the N-terminal. At the N-terminal, RND1 and RND3 (but not RND2) contain a KERRA (Lys-Glu-Arg-Arg-Ala) sequence that mediates their targeting to lipid rafts, and so their localization at the plasma membrane. |
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Bibliography | 1.Mouly L, Gilhodes J, Lemarié A, Cohen-Jonathan Moyal E, Toulas C, Favre G, Sordet O, Monferran S. The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis. Int J Mol Sci. 2019 Jul 24;20(15):3612. doi: 10.3390/ijms20153612. PMID: 31344837; PMCID: PMC6696182. 2.A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion.Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P J Cell Biol. 1998 Apr 6; 141(1):187-97. 3.Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP activation. Oinuma I, Kawada K, Tsukagoshi K, Negishi M Mol Biol Cell. 2012 Apr; 23(8):1593-604. 4.14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
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