Search by BoMiProt ID - Bomi8745


Primary Information

BoMiProt ID Bomi8745
Protein Name Rho GDP-dissociation inhibitor 3
Organism Bos taurus
Uniprot IdQ0II80
Milk FractionWhey
Ref Sequence Id NP_001069754.1
Aminoacid Length 225
Molecular Weight 25007
Fasta Sequence https://www.uniprot.org/uniprot/Q0II80.fasta
Gene Name ARHGDIG
Gene Id 613745
Protein Existence Status reviewed

Secondary Information

Protein Function Inhibits GDP/GTP exchange reaction of RhoB.
Biochemical Properties The NH2-terminal alpha helix of RhoGDI-3 is strongly amphipatic.Contained 21 additional amino acids in the NH2-terminal region .The incomplete RhoGDI-3 protein, lacking the first 68 NH2-terminal residues, could only interact with the GTP-bound RhoB-G14V protein. α-loop-α-loop secondary structure is important for specificity of the interaction between GDI-3 and Rho proteins.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions (30-54)
DisProt Annotation
TM Helix Prediction no TM helices
Bibliography Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B. RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J Biol Chem. 1996 Nov 29;271(48):30366-74. doi: 10.1074/jbc.271.48.30366. PMID: 8939998.