Search by BoMiProt ID - Bomi8733


Primary Information

BoMiProt ID Bomi8733
Protein Name Retinoic acid receptor responder protein 2/Chemerin
Organism Bos taurus
Uniprot IdQ29RS5
Milk FractionWhey
Ref Sequence Id NP_001039485.1
Aminoacid Length 162
Molecular Weight 18357
Fasta Sequence https://www.uniprot.org/uniprot/Q29RS5.fasta
Gene Name RARRES2
Gene Id 508990
Protein Existence Status reviewed

Secondary Information

Protein Function adipogenesis, glucose homeostasis, food intake and body weight.chemerin functions through Gi proteins to activate L-type Ca2+ channel and elicits a dose-dependent calcium influx in vascular smooth muscle cells, which underlies chemerin-induced vasocontraction and hypertension.Chemerin specifically bind and activate CMKLR1, which leads to Ca2+-mobilization and chemotaxis in dendritic cells (DC).
Biochemical Properties C terminal has YFPGQFAFS which acts as the most active fragment.
Significance in milk an adipokine involved in the regulation of metabolic and ovarian function in dairy cows.
PTMs Disulfide bond formation,Proteolytic cleavage
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 78-109, 132-141
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Secreted in an inactive precursor form, prochemerin, which is proteolytically processed by a variety of extracellular proteases to generate forms with differing levels of bioactivity.After truncation of the 20 amino acid N-terminal signal peptide, chemerin is secreted as 143 residue prochemerin
Additional Comments Increased serum chemerin that occurs with obesity is highly correlated with the development of Type 2 diabetes mellitus in humans.
Bibliography Helfer G, Wu QF. Chemerin: a multifaceted adipokine involved in metabolic disorders. J Endocrinol. 2018 Aug;238(2):R79-R94. doi: 10.1530/JOE-18-0174. Epub 2018 May 30. PMID: 29848608; PMCID: PMC6026924.