Primary Information |
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BoMiProt ID | Bomi8733 |
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Protein Name | Retinoic acid receptor responder protein 2/Chemerin |
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Organism | Bos taurus |
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Uniprot ID | Q29RS5 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001039485.1 |
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Aminoacid Length | 162 |
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Molecular Weight | 18357 |
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FASTA Sequence |
Download |
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Gene Name | RARRES2 |
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Gene ID | 508990 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | adipogenesis, glucose homeostasis, food intake and body weight.chemerin functions through Gi proteins to activate L-type Ca2+ channel and elicits a dose-dependent calcium influx in vascular smooth muscle cells, which underlies chemerin-induced vasocontraction and hypertension.Chemerin specifically bind and activate CMKLR1, which leads to Ca2+-mobilization and chemotaxis in dendritic cells (DC). |
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Biochemical Properties | C terminal has YFPGQFAFS which acts as the most active fragment. |
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Significance in milk | an adipokine involved in the regulation of metabolic and ovarian function in dairy cows. |
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PTMs | Disulfide bond formation,Proteolytic cleavage |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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Predicted Disorder Regions | 78-109, 132-141 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Secreted in an inactive precursor form, prochemerin, which is proteolytically processed by a variety of extracellular proteases to generate forms with differing levels of bioactivity.After truncation of the 20 amino acid N-terminal signal peptide, chemerin is secreted as 143 residue prochemerin |
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Additional Comments | Increased serum chemerin that occurs with obesity is highly correlated with the development of Type 2 diabetes mellitus in humans. |
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Bibliography | Helfer G, Wu QF. Chemerin: a multifaceted adipokine involved in metabolic disorders. J Endocrinol. 2018 Aug;238(2):R79-R94. doi: 10.1530/JOE-18-0174. Epub 2018 May 30. PMID: 29848608; PMCID: PMC6026924. |