Search by BoMiProt ID - Bomi8698


Primary Information

BoMiProt ID Bomi8698
Protein Name Regulator of microtubule dynamics protein 3/Protein FAM82A2/Protein FAM82C
Organism Bos taurus
Uniprot IdQ1JQC5
Milk FractionWhey
Ref Sequence Id NP_001069147.1
Aminoacid Length 471
Molecular Weight 51906
Fasta Sequence https://www.uniprot.org/uniprot/Q1JQC5.fasta
Gene Name RMDN3/FAM82A2 /FAM82C
Gene Id 514748
Protein Existence Status reviewed

Secondary Information

Protein Function Enables microtubule binding activity. Involved in cellular calcium ion homeostasis.
Biochemical Properties PTPIP51 belongs to a protein family that interacts with the microtubule cytoskeleton, also known as microtubule associated proteins, comprising three members specifically called regulator of microtubule dynamics (RMD).
PTMs Phosphorylation at Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q1JQC5|RMD3_BOVIN Regulator of microtubule dynamics protein 3 OS=Bos taurus OX=9913 GN=RMDN3 PE=2 SV=1 MSSLGTLGGARAGLGLLLGTAAGLGFLCALYSQRWKRTQRRGQS*44QS*46QSNS*50LDYTQTS*57EPG RQVRPLRAAPGEAGDAAVLSSLPRGQEVVLDRLEFVLTSLVALRREVEELRSSLQGLAGQ IVGEVRSHMEENQKVARRRRFPFARERSDSTGSSSVYFTAASGATFTDAESEGGYTTANA ES*182DYERDSERES*192DGDGEDEVSCETVKMGRKDS*212LDLEVEVALGLEPEAPEAGGS*233PGQEDVMPLLQQADELHQGSEQGKREGFQLLLNNKLVHGSRQDFLWRLARAYSDMCELTEEASEKRS YALSGKEEAEVALEKGNENAECHQWYAVLCGQLAEHEGIQRRIQSGFSFKEHVDKAIALK PENPMAHFLLGRWCYQVSHLSWLEKKTATALSESPLGATVQDALSSFLKAEELQPGFSKA GRIYICKCYKELGKNPEAKEWMKLALELPNVTKEDSAFQKDLEELEVILGE
Predicted Disorder Regions 39-76, 138-255
DisProt Annotation
TM Helix Prediction 1TMH; (13-31)
Significance of PTMs PTPIP51 has no endogenous enzymatic activity, It is assumed that the cellular functions of PTPIP51 are mediated through the previously described protein-protein-binding motifs and the resulting protein-protein interactions. These motifs and protein-protein interactions are under the influence of distinct tyrosine and serine phosphorylation sites in the PTPIP51 protein sequence.
Additional Comments  Located in several cellular components, including intercellular bridge; mitochondrial outer membrane; and spindle.
Bibliography 1.Yeo HK, Park TH, Kim HY, Jang H, Lee J, Hwang GS, Ryu SE, Park SH, Song HK, Ban HS, Yoon HJ, Lee BI. Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes. EMBO Rep. 2021 Jun 4;22(6):e51323. doi: 10.15252/embr.202051323. Epub 2021 May 2. PMID: 33938112; PMCID: PMC8183395. 2.Gomez-Suaga P, Paillusson S, Miller CCJ. ER-mitochondria signaling regulates autophagy. Autophagy. 2017 Jul 3;13(7):1250-1251. doi: 10.1080/15548627.2017.1317913. Epub 2017 May 26. PMID: 28548902; PMCID: PMC5529068. 3. Brobeil, Alexander; Dietel, Eric; Gattenlöhner, Stefan; Wimmer, Monika (2017).Orchestrating cellular signaling pathways—the cellular “conductor” protein tyrosine phosphatase interacting protein 51 (PTPIP51). Cell and Tissue Research, 368(3), 411–423.doi:10.1007/s00441-016-2508-5.