Search by BoMiProt ID - Bomi8685


Primary Information

BoMiProt ID Bomi8685
Protein Name Recombining binding protein suppressor of hairless
Organism Bos taurus
Uniprot IdQ3SZ41
Milk FractionWhey
Ref Sequence Id NP_001070469.1
Aminoacid Length 487
Molecular Weight 54341
Fasta Sequence https://www.uniprot.org/uniprot/Q3SZ41.fasta
Gene Name RBPJ
Gene Id 767928
Protein Existence Status reviewed

Secondary Information

Protein Function RBPJ is a key transcription factor downstream of Notch receptor activation
Biochemical Properties Recombination signal-binding protein Jκ (RBPJ) is a DNA-binding protein from CSL family of transcription factors [12]. RBPJ recognizes a consensus sequence C(T)GTGGGAA on RBPJ-binding sites from a number of factors [12]. Importantly, RBPJ also mediates signals from Notch receptors
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-18, 77-80, 152-162, 435-487
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments e downregulation of RBPJ expression resulted in a significant reduction of cell growth in transduced prostate cancer cells, confirmed by cell cycle analyses showing that knockdown of RBPJ decreased S-phase proliferating cells.
Bibliography Xue L, Li H, Chen Q, Wang Z, Zhang P, Chen H, Wang Z, Chong T. Inhibition of Recombining Binding Protein Suppressor of Hairless (RBPJ) Impairs the Growth of Prostate Cancer. Cell Physiol Biochem. 2015;36(5):1982-90. doi: 10.1159/000430166. Epub 2015 Jul 17. PMID: 26202358.