Primary Information
BoMiProt ID	Bomi8624
Protein Name	Rap1 GTPase-GDP dissociation stimulator 1/Exchange factor smgGDS/SMG GDS protein/SMG P21 stimulatory GDP/GTP exchange protein
Organism	Bos taurus
Uniprot ID	Q04173
Milk Fraction	Whey
Aminoacid Length	558
Molecular Weight	61067
FASTA Sequence	Download
Gene Name	RAP1GDS1
Protein Existence Status	reviewed
Secondary Information
Protein Function	Smg GDS is a regulator having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes.
Biochemical Properties	Structurally, it has 11 Arm repeats, a protein interaction motif, found in the Drosophila Armadillo protein, a homolog of mammalian beta-catenin.SMAP was a protein with a Mr of 91,189 and 792 amino acids. SMAP had 9 Arm repeats. Recombinant SMAP interacted with recombinant Smg GDS but did not affect the two activities of Smg GDS on RhoA.
PTMs	N6-Acetylation at Lys,Phosphorylation at Lys
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	SMAP was a protein with a Mr of 91,189 and 792 amino acids. SMAP had 9 Arm repeats. Recombinant SMAP interacted with recombinant Smg GDS but did not affect the two activities of Smg GDS on RhoA.
Additional Comments	SMAP was significantly homologous to sea urchin SpKAP115, suggesting that SMAP is a mammalian counterpart of SpKAP115 or its related protein. SpKAP115 is an accessory subunit of sea urchin kinesin II, an ATPase motor that transports vesicles along microtubules.
Bibliography	Shimizu K, Kawabe H, Minami S, Honda T, Takaishi K, Shirataki H, Takai Y. SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase. J Biol Chem. 1996 Oct 25;271(43):27013-7. doi: 10.1074/jbc.271.43.27013. PMID: 8900189.