Search by BoMiProt ID - Bomi8554


Primary Information

BoMiProt ID Bomi8554
Protein Name Pyruvate carboxylase, mitochondrial/Pyruvic carboxylase/PCB
Organism Bos taurus
Uniprot IdQ29RK2
Milk Fractionwhey
Ref Sequence Id NP_808815.2
Aminoacid Length 1178
Molecular Weight 129698
Fasta Sequence https://www.uniprot.org/uniprot/Q29RK2.fasta
Gene Name PC
Gene Id 338471
Protein Existence Status Reviewed

Secondary Information

Protein Function Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate
Significance in milk Expression changes during transition to lactation and feed restriction in dairy cows
PTMs Acetylation and Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Acetylation of Lys-748 might play a role in catalytic activity regulation
Bibliography Agca, C., Bidwell, C. A., & Donkin, S. S. (2004). Cloning of bovine pyruvate carboxylase and 5' untranslated region variants. Animal biotechnology, 15(1), 47–66. https://doi.org/10.1081/ABIO-120037897