Primary Information |
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| BoMiProt ID | Bomi8528 |
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| Protein Name | Putative deoxyribonuclease TATDN1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q148G4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001068870.1 |
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| Aminoacid Length | 297 |
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| Molecular Weight | 33886 |
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| FASTA Sequence |
Download |
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| Gene Name | TATDN1 |
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| Gene ID | 509365 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Zebrafish TATDN1 (zTATDN1) possesses a novel endonuclease activity, which first makes a nick at the DNA duplex and subsequently converts the nick into a DNA double-strand break in vitro. |
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| Biochemical Properties | The biochemical property allows zTATDN1 to catalyze decatenation of catenated kinetoplast DNA to produce separated linear DNA in vitro. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | zTATDN1 is predominantly expressed in eye cells during embryonic development. Knockdown of TATDN1 in zebrafish embryos results in an abnormal cell cycle progression, formation of polyploidy and aberrant chromatin structures. |
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| Bibliography | Yang H, Liu C, Jamsen J, Wu Z, Wang Y, Chen J, Zheng L, Shen B. The DNase domain-containing protein TATDN1 plays an important role in chromosomal segregation and cell cycle progression during zebrafish eye development. Cell Cycle. 2012 Dec 15;11(24):4626-32. doi: 10.4161/cc.22886. Epub 2012 Nov 27. PMID: 23187801; PMCID: PMC3562307. |
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