Search by BoMiProt ID - Bomi8528


Primary Information

BoMiProt ID Bomi8528
Protein Name Putative deoxyribonuclease TATDN1
Organism Bos taurus
Uniprot IdQ148G4
Milk FractionWhey
Ref Sequence Id NP_001068870.1
Aminoacid Length 297
Molecular Weight 33886
Fasta Sequence https://www.uniprot.org/uniprot/Q148G4.fasta
Gene Name TATDN1
Gene Id 509365
Protein Existence Status reviewed

Secondary Information

Protein Function Zebrafish TATDN1 (zTATDN1) possesses a novel endonuclease activity, which first makes a nick at the DNA duplex and subsequently converts the nick into a DNA double-strand break in vitro. 
Biochemical Properties The biochemical property allows zTATDN1 to catalyze decatenation of catenated kinetoplast DNA to produce separated linear DNA in vitro. 
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments  zTATDN1 is predominantly expressed in eye cells during embryonic development. Knockdown of TATDN1 in zebrafish embryos results in an abnormal cell cycle progression, formation of polyploidy and aberrant chromatin structures. 
Bibliography Yang H, Liu C, Jamsen J, Wu Z, Wang Y, Chen J, Zheng L, Shen B. The DNase domain-containing protein TATDN1 plays an important role in chromosomal segregation and cell cycle progression during zebrafish eye development. Cell Cycle. 2012 Dec 15;11(24):4626-32. doi: 10.4161/cc.22886. Epub 2012 Nov 27. PMID: 23187801; PMCID: PMC3562307.