Search by BoMiProt ID - Bomi8460


Primary Information

BoMiProt ID Bomi8460
Protein Name Protein-L-isoaspartate(D-aspartate) O-methyltransferase/L-isoaspartyl protein carboxyl methyltransferase/Protein-beta-aspartate methyltransferase
Organism Bos taurus
Uniprot IdP15246
Milk FractionWhey
Ref Sequence Id NP_001073085.1
Aminoacid Length 227
Molecular Weight 24565
Fasta Sequence https://www.uniprot.org/uniprot/P15246.fasta
Gene Name PCMT1
Gene Id 613854
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells semitendinosus
Protein Function Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) is identified as an Mst1-interacting protein.PCMT1 as a novel inhibitor of Mst1 activation in cardiomyocytes and suggest that targeting PCMT1 may prevent myocardial apoptosis through inhibition of Mst1.
PTMs N-acetylation at Alanine
Additional Comments deletion of PCMT1 significantly alters red blood cell metabolism in a healthy state, but does not impair the circulatory lifespan of red blood cells. 
Linking IDs Bomi8460
Bibliography 1.D'Alessandro A, Hay A, Dzieciatkowska M, Brown BC, Morrison EJ, Hansen KC, Zimring JC. Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells. Haematologica. 2021 Oct 1;106(10):2726-2739. doi: 10.3324/haematol.2020.266676. PMID: 33054131; PMCID: PMC8485689. 2.Yan G, Qin Q, Yi B, Chuprun K, Sun H, Huang S, Sun J. Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1. Int J Cardiol. 2013 Oct 9;168(4):3291-9. doi: 10.1016/j.ijcard.2013.04.045. Epub 2013 May 3. PMID: 23647599; PMCID: PMC3788851.
Presence in other biological fluids/tissue/cells semitendinosus
Protein Function Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) is identified as an Mst1-interacting protein.PCMT1 as a novel inhibitor of Mst1 activation in cardiomyocytes and suggest that targeting PCMT1 may prevent myocardial apoptosis through inhibition of Mst1.
PTMs N-acetylation at Alanine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments deletion of PCMT1 significantly alters red blood cell metabolism in a healthy state, but does not impair the circulatory lifespan of red blood cells. 
Linking IDs
Bibliography 1.D'Alessandro A, Hay A, Dzieciatkowska M, Brown BC, Morrison EJ, Hansen KC, Zimring JC. Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells. Haematologica. 2021 Oct 1;106(10):2726-2739. doi: 10.3324/haematol.2020.266676. PMID: 33054131; PMCID: PMC8485689. 2.Yan G, Qin Q, Yi B, Chuprun K, Sun H, Huang S, Sun J. Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1. Int J Cardiol. 2013 Oct 9;168(4):3291-9. doi: 10.1016/j.ijcard.2013.04.045. Epub 2013 May 3. PMID: 23647599; PMCID: PMC3788851.