Primary Information |
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| BoMiProt ID | Bomi8438 |
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| Protein Name | Protein transport protein Sec23A/SEC23-related protein A |
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| Organism | Bos taurus |
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| Uniprot ID | A2VDL8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001075073.1 |
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| Aminoacid Length | 768 |
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| Molecular Weight | 86674 |
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| FASTA Sequence |
Download |
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| Gene Name | SEC23A |
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| Gene ID | 533994 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | involved in intracellular protein transport and autophagy.Sec23 is a component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) to golgi. |
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| PTMs | phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A2VDL8|SC23A_BOVIN Protein transport protein Sec23A OS=Bos taurus OX=9913 GN=SEC23A PE=2 SV=1
MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVL
CSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPTYAGISELNQPAELLPQFSSIEYV
VLRGPQMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLITFGRMVQVHELGC
EGISKSYVFRGTKDLSAKQLQEMLGLSKVPVTQATRGPQVQQPPPSNRFLQPVQKIDMNL
TDLLGELQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGM
VVGDELKT*308PIRSWHDIEKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEM
KCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGGTLEIKTSREIKISGAI
GPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNAPIPQGGRGAIQ
FVTQYQHSSGQRRIRVTTIARNWADAQTQIQNIAASFDQEAAAILMARLAIYRAETEEGP
DVLRWLDRQLIRLCQKFGEYHKDDPSSFRFSETFSLYPQFMFHLRRSPFLQVFNNSPDES
SYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYH
GETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLS
KVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKTCCVKCCLMC
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | serine 207, serine 312 and threonine 405 on Sec23A are phosphorylated by ULK1.ULK1 phosphorylates Sec23A at residues serine 207 and threonine 405 and thereby, reduces traffic at ERES.Serine207 of Sec23A is important for Sec31A binding.Phosphorylation at Tyr-737 by SRC occurs at the plasma membrane in clathrin-coated vesicles (CCVs) |
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| Bibliography | Gan W, Zhang C, Siu KY, Satoh A, Tanner JA, Yu S. ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic. BMC Cell Biol. 2017 May 10;18(1):22. doi: 10.1186/s12860-017-0138-8. PMID: 28486929; PMCID: PMC5424413. |
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