Search by BoMiProt ID - Bomi8419


Primary Information

BoMiProt ID Bomi8419
Protein Name Protein S100-A4/Metastasin/Placental calcium-binding protein homolog/S100 calcium-binding protein A4
Organism Bos taurus
Uniprot IdP35466
Milk FractionWhey
Ref Sequence Id NP_777020.1
Aminoacid Length 101
Molecular Weight 11807
Fasta Sequence https://www.uniprot.org/uniprot/P35466.fasta
Gene Name S100A4/CAPL
Gene Id 282343
Protein Existence Status reviewed

Secondary Information

Protein Function Calcium-binding protein.angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9.Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels.A potent trigger of inflammatory processes and induces the release of cytokines and growth factors.
Biochemical Properties Homodimer
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 4 predicted segments; (1-5), (25-27), (46-51), (89-101)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Ambartsumian N, Klingelhöfer J, Grigorian M. The Multifaceted S100A4 Protein in Cancer and Inflammation. Methods Mol Biol. 2019;1929:339-365. doi: 10.1007/978-1-4939-9030-6_22. PMID: 30710284.