Primary Information |
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| BoMiProt ID | Bomi8419 |
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| Protein Name | Protein S100-A4/Metastasin/Placental calcium-binding protein homolog/S100 calcium-binding protein A4 |
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| Organism | Bos taurus |
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| Uniprot Id | P35466 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_777020.1 |
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| Aminoacid Length | 101 |
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| Molecular Weight | 11807 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/P35466.fasta |
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| Gene Name | S100A4/CAPL |
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| Gene Id | 282343 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Calcium-binding protein.angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9.Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels.A potent trigger of inflammatory processes and induces the release of cytokines and growth factors. |
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| Biochemical Properties | Homodimer |
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| PTMs | Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 4 predicted segments; (1-5), (25-27), (46-51), (89-101) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Ambartsumian N, Klingelhöfer J, Grigorian M. The Multifaceted S100A4 Protein in Cancer and Inflammation. Methods Mol Biol. 2019;1929:339-365. doi: 10.1007/978-1-4939-9030-6_22. PMID: 30710284. |
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