Search by BoMiProt ID - Bomi8366


Primary Information

BoMiProt ID Bomi8366
Protein Name Protein MMS22-like/Methyl methanesulfonate-sensitivity protein 22-like
Organism Bos taurus
Uniprot IdE1BGH8
Milk FractionWhey
Aminoacid Length 1244
Molecular Weight 142274
Fasta Sequence https://www.uniprot.org/uniprot/E1BGH8.fasta
Gene Name MMS22L
Protein Existence Status reviewed

Secondary Information

Protein Function Budding yeast Mms22 is required for homologous recombination (HR)-mediated repair of stalled or broken DNA replication forks.
Biochemical Properties C6ORF167/MMS22L as a putative human ortholog of yeast Mms22 and on the one hand, there are striking functional similarities between MMS22L and yeast Mms22.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction no TM helices
Additional Comments Depletion of MMS22L or TONSL from human cells causes a high level of double-strand breaks (DSBs) during DNA replication. 
Bibliography Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J. Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell. 2010 Nov 24;40(4):632-44. doi: 10.1016/j.molcel.2010.10.023. Epub 2010 Nov 4. PMID: 21055984.