Primary Information |
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| BoMiProt ID | Bomi8366 |
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| Protein Name | Protein MMS22-like/Methyl methanesulfonate-sensitivity protein 22-like |
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| Organism | Bos taurus |
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| Uniprot Id | E1BGH8 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 1244 |
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| Molecular Weight | 142274 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/E1BGH8.fasta |
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| Gene Name | MMS22L |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Budding yeast Mms22 is required for homologous recombination (HR)-mediated repair of stalled or broken DNA replication forks. |
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| Biochemical Properties | C6ORF167/MMS22L as a putative human ortholog of yeast Mms22 and on the one hand, there are striking functional similarities between MMS22L and yeast Mms22. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Additional Comments | Depletion of MMS22L or TONSL from human cells causes a high level of double-strand breaks (DSBs) during DNA replication. |
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| Bibliography | Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J. Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell. 2010 Nov 24;40(4):632-44. doi: 10.1016/j.molcel.2010.10.023. Epub 2010 Nov 4. PMID: 21055984. |
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