Primary Information |
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| BoMiProt ID | Bomi8358 |
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| Protein Name | Protein kintoun/Dynein assembly factor 2, axonemal |
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| Organism | Bos taurus |
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| Uniprot Id | Q0VC73 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_001069492.2 |
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| Aminoacid Length | 829 |
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| Molecular Weight | 90970 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/Q0VC73.fasta |
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| Gene Name | DNAAF2/KTU |
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| Gene Id | 534465 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Required for cytosolic pre-assembly of axonemal dyneins and play a central role in motility in cilia and flagella. |
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| Biochemical Properties | Its homologue in single-celled alga Chlamydomonas is known as PF13. |
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| PTMs | Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0VC73|KTU_BOVIN Protein kintoun OS=Bos taurus OX=9913 GN=DNAAF2 PE=2 SV=2
MAKEAASSPLEDLDLSGEEVQRLTSAFQDPEFRRMFSEYAEELTDPENRRRYEEEITALE
RERGVEVRFVHPEPGHVLRTSLDGTRRCFVNVCSNALVGAPSSQPGSGSAVSGRQWSLPY
SLAPGREYAWGRGTRYTVYDVVFHPDAIALARRHERFRQMLDATALEAVEKQFGVKLDRR
NAKTLKIKYKGTPDAAVLRTPLPGGAPARPEGEPESPFPDFPYPYRYPAAGASAAVPRPQ
APSPPEAVRQPAPTEPRYSVVQRHHVDLQDYRCSRDSAPGTVPQELVVTIELPLLRSAEQ
AALEVTGKLLCLDSRKPDYRLRLSLPYPVDDSRGKAQFNKARRQLVVTLPVAPTASRPEP
AASPEEAADPPGTDGAACASACRGEAGPAGVCAGDAISGPSRTRAADAGITTPDAPGKER
VAKSEERDFGGQEISTTGTREEPPSGAGNS*450PGDRGGGALSTSWGDLDAGLSVGSASVRPT
LGVEARETREGTGREPAYRAMGGPGTDRGEALCPPLQCSQDEESLTLLVQVPWILLQSLQ
GEVNPLWYKLSFSTQDLVYYSFFLQFTPENKLSTKEPEVSISSNNAVINLAKSPECHGYW
REWYYGLNNYCLEERLFVNEDNVNEFLEEVLS*632PPFKQTLPLTPPLIEVLQVTDSKIEIHA
KLQECSNSEQLHEKEERVHEGSPLTEKENTEHATISTTDSASSVAVTVLEADRCGSATCL
QQGALDVSQKLFAESQQPKSEKEREFIKDKSAVYANERKDNLKEPVITEEKELDGNHPSS
LLNKTAVRDTPGFDHIKETNMQDGSVQIIKDHVTHCSFSFQNNLLYDLD
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| Predicted Disorder Regions | 1-11, 222-238, 256-274, 365-469, 490-504, 675-702, 718-758, 781-785 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Additional Comments | A mutation in Ktu/PF13 has been identified in some patients with primary ciliary dyskinesia (PCD). |
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| Bibliography | Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins. Omran H, Kobayashi D, Olbrich H, Tsukahara T, Loges NT, Hagiwara H, Zhang Q, Leblond G, O'Toole E, Hara C, Mizuno H, Kawano H, Fliegauf M, Yagi T, Koshida S, Miyawaki A, Zentgraf H, Seithe H, Reinhardt R, Watanabe Y, Kamiya R, Mitchell DR, Takeda H. Nature 456, 611-6, (2008). View articlePMID: 19052621 |
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