Primary Information | |
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BoMiProt ID | Bomi8323 |
Protein Name | Protein chibby homolog 2/Spermatid-associated protein |
Organism | Bos taurus |
Uniprot ID | A6QQS3 |
Milk Fraction | whey |
Ref Sequence ID | NP_001095767.1 |
Aminoacid Length | 455 |
Molecular Weight | 52473 |
FASTA Sequence | Download |
Gene Name | CBY2/SPERT |
Gene ID | 616053 |
Protein Existence Status | Reviewed |
Secondary Information | |
Protein Function | CBY2 is a testis-specific leucine-zipper protein that interacts with NEK1 during late spermatid maturation. |
Biochemical Properties | contain an N-terminal leucine-zipper motif, 2 C-terminal coiled-coil regions, and several phosphorylation sites. |
PTMs | Phosphorylation |
Additional Comments | In situ hybridization, immunofluorescence analysis, and immunoelectron microscopy showed that Cby2 was expressed in inner cell layers within seminiferous tubules and formed large aggregates in flower-like structure organelles in cytoplasm. |
Linking IDs | Bomi8323 |
Bibliography | Chen, S. Z., & Zheng, L. Z. (2021). SPERT gene silencing inhibits the growth of human colon cancer xenograft tumor in nude mice via p38MAPK/HSP27 signaling pathway. Biomedical research (Tokyo, Japan), 42(6), 247–255. https://doi.org/10.2220/biomedres.42.247 |
Protein Function | CBY2 is a testis-specific leucine-zipper protein that interacts with NEK1 during late spermatid maturation. |
Biochemical Properties | contain an N-terminal leucine-zipper motif, 2 C-terminal coiled-coil regions, and several phosphorylation sites. |
PTMs | Phosphorylation |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|A6QQS3|CBY2_BOVIN Protein chibby homolog 2 OS=Bos taurus OX=9913 GN=CBY2 PE=2 SV=2 MSPLECSECFGDQLLHRTYTWHLTLHSRPNFTRKRDTRSES*41LEIPINVVLPQRGTAEPFL RLHNLYPTPRCARQAALPRLSRRVVS*86QHS*89YPLNRFSS*97VPLDPMERPTSQADLELDYNPPR VQLS*124DEMFVFQDGRWVSENCRLQS*144PYFS*148PS*150SSFHHKLHHKRLAKECLLQENKTLREENRALREENRMLRKENKILQVFWEEHQAALGRDDS*211RASSPLLHKDNASS*225LEAMKKETALQAHRGRENSTLQLLREENRALQQLLEQRKAYWAQPDEKAAS*276TEEIKPISSPHEEPHGLLPDPGPG LPSPFEEPKGLPAPPDDSKTLRALREMVSTLS*332AQPGEEVGKGGPGLPDGSQSLELLREMN QALQALREENQSLQVLRDENRLLQEENRALHALREEHRLFQEENKALWENNKLKLQQKLV IDTVTEVTARMEMLIEELYAFMPAKSKDPKKPSRV |
Predicted Disorder Regions | 95-118, 209-320, 330-409, 444-451 |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
Additional Comments | In situ hybridization, immunofluorescence analysis, and immunoelectron microscopy showed that Cby2 was expressed in inner cell layers within seminiferous tubules and formed large aggregates in flower-like structure organelles in cytoplasm. |
Linking IDs | |
Bibliography | Chen, S. Z., & Zheng, L. Z. (2021). SPERT gene silencing inhibits the growth of human colon cancer xenograft tumor in nude mice via p38MAPK/HSP27 signaling pathway. Biomedical research (Tokyo, Japan), 42(6), 247–255. https://doi.org/10.2220/biomedres.42.247 |