Search by BoMiProt ID - Bomi8320


Primary Information

BoMiProt ID Bomi8320
Protein Name Protein associated with UVRAG as autophagy enhancer/ Pacer/Protein Rubicon-like
Organism Bos taurus
Uniprot IdA7E316
Milk FractionWhey
Ref Sequence Id NP_001095511.1
Aminoacid Length 663
Molecular Weight 73604
Fasta Sequence https://www.uniprot.org/uniprot/A7E316.fasta
Gene Name RUBCNL
Gene Id 517231
Protein Existence Status reviewed

Secondary Information

Protein Function Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns3P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex.
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-132, 148-180
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Acetylated by KAT5/TIP60 under autophagy induction, promoting autophagosome maturation and lipid metabolism. Lys-484 and Lys-574 constitute the key sites for tuning function in autophagy.
Bibliography Cheng, X., Ma, X., Ding, X., Li, L., Jiang, X., Shen, Z., Chen, S., Liu, W., Gong, W., & Sun, Q. (2017). Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17. Molecular cell, 65(6), 1029–1043.e5. https://doi.org/10.1016/j.molcel.2017.02.010