Search by BoMiProt ID - Bomi8318


Primary Information

BoMiProt ID Bomi8318
Protein Name Protein arginine N-methyltransferase 7/Histone-arginine N-methyltransferase PRMT7/[Myelin basic protein]-arginine N-methyltransferase PRMT7
Organism Bos taurus
Uniprot IdA6QQV6
Milk FractionWhey
Ref Sequence Id NP_001095460.1
Aminoacid Length 695
Molecular Weight 78654
Fasta Sequence https://www.uniprot.org/uniprot/A6QQV6.fasta
Gene Name PRMT7
Gene Id 514202
Protein Existence Status reviewed

Secondary Information

Protein Function Protein arginine methyltransferases (PRMTs) catalyze protein arginine methylation and are linked to carcinogenesis and metastasis.
Biochemical Properties The PRMT family consists of ten PRMT proteins (PRMT 1–10) that have been identified to date, and all PRMT proteins, except PRMT8, are expressed in various tissues. However, PRMT expression in macrophages has not been investigated.The main function of PRMT5 and PRMT7 lies in Vpr-mediated virus production in macrophages.
PTMs Methylation at Arg 153
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction no TM helices
Significance of PTMs Automethylation of PRMT7 at R531, plays a key role in inducing the epithelial-mesenchymal transition (EMT) program and in promoting the migratory and invasive behavior of breast cancer cells. 
Additional Comments PRMT7 is indeed a type III human methyltransferase capable of forming only ω-N(G)-monomethylarginine, not asymmetric ω-N(G),N(G)-dimethylarginine or symmetric ω-N(G),N(G')-dimethylarginine
Bibliography 1.Geng P, Zhang Y, Liu X, Zhang N, Liu Y, Liu X, Lin C, Yan X, Li Z, Wang G, Li Y, Tan J, Liu DX, Huang B, Lu J. Automethylation of protein arginine methyltransferase 7 and its impact on breast cancer progression. FASEB J. 2017 Jun;31(6):2287-2300. doi: 10.1096/fj.201601196R. Epub 2017 Feb 10. PMID: 28188177. 2.Zurita-Lopez CI, Sandberg T, Kelly R, Clarke SG. Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming ω-NG-monomethylated arginine residues. J Biol Chem. 2012 Mar 9;287(11):7859-70. doi: 10.1074/jbc.M111.336271. Epub 2012 Jan 12. PMID: 22241471; PMCID: PMC3318701. 3.Murakami H, Suzuki T, Tsuchiya K, Gatanaga H, Taura M, Kudo E, Okada S, Takei M, Kuroda K, Yamamoto T, Hagiwara K, Dohmae N, Aida Y. Protein Arginine N-methyltransferases 5 and 7 Promote HIV-1 Production. Viruses. 2020 Mar 23;12(3):355. doi: 10.3390/v12030355. PMID: 32210193; PMCID: PMC7150949.