Primary Information |
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| BoMiProt ID | Bomi8257 |
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| Protein Name | Proline/serine-rich coiled-coil protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q29RJ9 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039966.1 |
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| Aminoacid Length | 326 |
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| Molecular Weight | 34326 |
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| FASTA Sequence |
Download |
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| Gene Name | PSRC1 |
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| Gene ID | 541250 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | PSRC1 protects against the development of atherosclerosis and enhances the stability of plaques by modulating cholesterol transportation and inflammation in macrophages and the liver of apoE-/- mice. |
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| Biochemical Properties | Psrc1 may mediate the interactions between p53 and other signaling pathways and contribute to the complexity and specificity of the p53 signaling network. |
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| PTMs | Phosphorylation at Ser/Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q29RJ9|PSRC1_BOVIN Proline/serine-rich coiled-coil protein 1 OS=Bos taurus OX=9913 GN=PSRC1 PE=2 SV=1
MEDLEEDVKFIADETLDFGGLS*22PSDSREEEDVAVLVTPEKPLRRGLS*47HRSDPNAVAPTPQ
GLRLS*65LGPLS*70PEKLEEILHEANRLAAQLEQCALKERENTGEGSGPRRVKPSPRRETFVLK
DS*122PVRDLLPTVSSLARSTPS*140PSSLT*145PRLRSSDRKGSIRALRATSGKKPSSVKRESPTCNL
FPASKS*186PASS*190PLARSAPPVRGKAGPSGRATASPPTPVRPVLAPQPPAGSSQRPSRPQGAA
AKPSSRLPVPSAVPRPGNRMPLASRSVPSSKGAPPSDSLSARKGLPRPSAAGHRVPVSQR
PNLPISGAGRSNLQPPRKVAVPGSTR
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| Predicted Disorder Regions | 1-80, 86-257, 267-294, 319-326 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | PSRC1 overexpression attenuates atherosclerosis progression in apoE -/- mice by modulating cholesterol transportation and inflammation |
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| Bibliography | 1.Guo K, Hu L, Xi D, Zhao J, Liu J, Luo T, Ma Y, Lai W, Guo Z. PSRC1 overexpression attenuates atherosclerosis progression in apoE-/- mice by modulating cholesterol transportation and inflammation. J Mol Cell Cardiol. 2018 Mar;116:69-80. doi: 10.1016/j.yjmcc.2018.01.013. Epub 2018 Feb 3. PMID: 29378206. |
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