Search by BoMiProt ID - Bomi8239


Primary Information

BoMiProt ID Bomi8239
Protein Name Profilin-2
Organism Bos taurus
Uniprot IdQ09430
Milk FractionExosomes
Ref Sequence Id NP_001121669.1
Aminoacid Length 140
Molecular Weight 15032
Fasta Sequence https://www.uniprot.org/uniprot/Q09430.fasta
Gene Name PFN2
Gene Id 539034
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells  occipital lobe 
Protein Function PFN2 promotes the proliferation, migration and invasion of TNBC cells by regulating epithelial-to-mesenchymal transition.
PTMs N-acetylation at Alanine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments PFN2 increased, whereas its knockdown (KD) decreased the proliferation, migration, and invasion of SCLC cell H446. 
Bibliography 1.Cao Q, Liu Y, Wu Y, Hu C, Sun L, Wang J, Li C, Guo M, Liu X, Lv J, Huo X, Yue J, Du X, Chen Z. Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes. Aging (Albany NY). 2020 Nov 21;12(24):25981-25999. doi: 10.18632/aging.202213. Epub 2020 Nov 21. PMID: 33234737; PMCID: PMC7803489. 2.Ling Y, Cao Q, Liu Y, Zhao J, Zhao Y, Li K, Chen Z, Du X, Huo X, Kang H, Chen Z. Profilin 2 (PFN2) promotes the proliferation, migration, invasion and epithelial-to-mesenchymal transition of triple negative breast cancer cells. Breast Cancer. 2021 Mar;28(2):368-378. doi: 10.1007/s12282-020-01169-x. Epub 2020 Oct 12. PMID: 33047272.