Search by BoMiProt ID - Bomi8228


Primary Information

BoMiProt ID Bomi8228
Protein Name Probetacellulin
Organism Bos taurus
Uniprot IdQ9TTC5
Milk FractionWhey
Ref Sequence Id NP_776321.2
Aminoacid Length 178
Molecular Weight 19640
Fasta Sequence https://www.uniprot.org/uniprot/Q9TTC5.fasta
Gene Name BTC
Gene Id 280737
Protein Existence Status reviewed

Secondary Information

Presence in other biological fluids/tissue/cells present in the pancreas,plays role in the differentiation of pancreatic β cells.
Protein Function A neonatal developmental protein.Serves as growth factor which binds to EGFR, ERBB4 and other EGF receptor family members.Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. 
Biochemical Properties Contains a signal peptide,the extracellular region including EGF like domain,a transmebrane domain and a cytosolic tail.BTC EGF-like motif includes six conserved cysteine residues with three disulfide-bonded intramolecular loops (A-loop: Cys69–Cys82; B-loop: Cys77–Cys93; C-loop: Cys95–Cys104).Human BTC contains RGD sequence which facilitate binding to integrin thus cell to cell ineraction.
Significance in milk neonatal developmental protein
PTMs Disulfide bond formation,Glycosylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q9TTC5|BTC_BOVIN Probetacellulin OS=Bos taurus OX=9913 GN=BTC PE=2 SV=1 MARAAPGSGASPLPLLPALALGLVILHCVVADGN*34STRSPEDDGLLCGDHAENCPATTTQP KRRGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYAGARCERVDLFYLRGDRGQIL VICLIAVMVIFIILVVSICTCCHPLRKRRKRRKKEEEMETLGKDITPINDDIQETSIA
Predicted Disorder Regions 5; (2 short and 3 long) predicted disordered segments.(1-10), 49th residue, 58th residue, (68-72), (153-178)
DisProt Annotation NA
TM Helix Prediction 2 TMHs: (13 to 21 ) and (117 -139)
Significance of PTMs BTC contains six conserved cysteine residues with three disulfide-bonded intramolecular loops (A-loop: Cys69–Cys82; B-loop: Cys77–Cys93; C-loop: Cys95–Cys104).The most important PTM of BTC is ectodomain shedding,the proteolytic release of a soluble growth factor able to bind and activate ERBB receptors in neighboring cells (paracrine signaling) or in the cell of its origin (autocrine signaling).Mature human BTC contains 80 amino acids, extending from Asp32 to Tyr111.
Bibliography Dahlhoff M, Wolf E, Schneider MR. The ABC of BTC: structural properties and biological roles of betacellulin. Semin Cell Dev Biol. 2014 Apr;28:42-8. doi: 10.1016/j.semcdb.2014.01.002. Epub 2014 Jan 15. PMID: 24440602.