Search by BoMiProt ID - Bomi8224


Primary Information

BoMiProt ID Bomi8224
Protein Name Probable tubulin polyglutamylase TTLL1/Tubulin polyglutamylase complex subunit 3/Tubulin--tyrosine ligase-like protein 1
Organism Bos taurus
Uniprot IdQ0VC71
Milk FractionWhey
Ref Sequence Id NP_001069639.1
Aminoacid Length 423
Molecular Weight 49030
Fasta Sequence https://www.uniprot.org/uniprot/Q0VC71.fasta
Gene Name TTLL1
Gene Id 539530
Protein Existence Status reviewed

Secondary Information

Protein Function TTLL1 complex may be involved in tubulin substrate recognition, regulation of enzymatic activity, or subcellular localization
Biochemical Properties TTLL1 is a member of a large family of proteins with a TTL homology domain, whose members could catalyze ligations of diverse amino acids to tubulins or other substrates.The amino acid sequence of TTLL1 (PGs3) contains three conserved motifs that correspond to the adenosine triphosphate (ATP)/Mg2þ-binding site typical of enzymes with a carboxylateamine/thiol ligase activity, such as glutathione synthetase.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments TTLL1 and TTL are members of a large family of conserved eukaryotic proteins with a TTL homology domain, which raises the possibility that other members of this family are also involved in polyglutamylation or other types of posttranslational amino acid ligations
Bibliography 1.Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Eddé B. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science. 2005 Jun 17;308(5729):1758-62. doi: 10.1126/science.1113010. Epub 2005 May 12. PMID: 15890843. 2.C. Regnard et al., J. Cell Sci. 116, 4181 (2003).