Search by BoMiProt ID - Bomi8207


Primary Information

BoMiProt ID Bomi8207
Protein Name Pre-mRNA-splicing factor RBM22/RNA-binding motif protein 22
Organism Bos taurus
Uniprot IDQ3B7L8
Milk FractionWhey
Ref Sequence ID NP_001032907.1
Aminoacid Length 420
Molecular Weight 46930
FASTA Sequence Download
Gene Name RBM22
Gene ID 512330
Protein Existence Status reviewed

Secondary Information

Protein Function Pre-spliceosome assembly.interaction with U2–U6 snRNA and its stabilization during spliceosome formation.
Biochemical Properties RNA-binding motif protein with a conserved RNA-binding domain, a zinc finger domain C-x8-C-x5-C-x3-H, and a C-terminus that is unusually rich in the amino acids Gly and Pro, including sequences of tetraprolines.
PTMs Acetylation and phosphorylation on Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q3B7L8|RBM22_BOVIN Pre-mRNA-splicing factor RBM22 OS=Bos taurus OX=9913 GN=RBM22 PE=2 SV=1 MATS*4LGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPG VRMRFKKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLS*102FKDDMPKSDVNKEYYTQN MEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECP YRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRASTMPRLDPPEDKTITTLYVGGLG DTITETDLRNHFYQFGEIRTITVVQRQQCAFIQFATRQAAEVAAEKSFNKFIVNGRRLNV KWGRSQAARGKEKEKDGTTDSGIKLEPVPGLPGALPPPPAAEEEASANYFNLPPSGPPAV VNIALPPPPGIAPPPPPGFGPHMFHPMGPPPPFMRAPGPIHYPSQDPQRMGAHAGKHSSP
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Ciavarella J, Perea W, Greenbaum NL. Topology of the U12-U6atac snRNA Complex of the Minor Spliceosome and Binding by NTC-Related Protein RBM22. ACS Omega. 2020 Sep 4;5(37):23549-23558. doi: 10.1021/acsomega.0c01674. PMID: 32984674; PMCID: PMC7512442.2.He F, Wang CT, Gou LT. RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos. Genet Mol Res. 2009 Dec 8;8(4):1466-73. doi: 10.4238/vol8-4gmr683. PMID: 20013661.