Protein Function | Prefoldin (PFDN),assists the folding of newly synthesized proteins and prevents the aggregation and misfolding of preexisting proteins. PFDN5 prevents aggregation of misfolded proteins such as a pathogenic form of amyloid β, huntingtin, and α-synuclein, causative gene product of Alzheimer’s disease (AD), Huntington’s disease, and Parkinson’s disease, respectively, and subsequent neuronal cell death. |
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Bibliography | 1.Kadoyama K, Matsuura K, Takano M, Maekura K, Inoue Y, Matsuyama S. Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus. Neurosci Lett. 2019 Nov 1;712:134484. doi: 10.1016/j.neulet.2019.134484. Epub 2019 Sep 7. PMID: 31505240. 2.R. Siegert, M.R. Leroux, C. Scheufler, F.U. Hartl, I. Moarefi.Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins.Cell, 103 (2000), pp. 621-632. 3.K.M. Sörgjerd, T. Zako, M. Sakono, P.C. Stirling, M.R. Leroux, T. Saito, P. Nilsson, M. Sekimoto, T.C. Saido, M. Maeda
Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates.Biochemistry, 52 (2013), pp. 3532-3542. 4.E. Tashiro, T. Zako, H. Muto, Y. Itoo, K. Sörgjerd, N. Terada, A. Abe, M. Miyazawa, A. Kitamura, H. Kitaura, H. Kubota, M. Maeda, T. Momoi, S.M. Iguchi-Ariga, M. Kinjo, H. Ariga.Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation.J. Biol. Chem., 288 (2013), pp. 19958-19972. 5.M. Takano, E. Tashiro, A. Kitamura, H. Maita, S.M. Iguchi-Ariga, M. Kinjo, H. Ariga.Prefoldin prevents aggregation of α-synuclein.Brain Res., 1542 (2014), pp. 186-194. |