Search by BoMiProt ID - Bomi8173


Primary Information

BoMiProt ID Bomi8173
Protein Name Potassium voltage-gated channel subfamily KQT member 3/KQT-like 3/Potassium channel subunit alpha KvLQT3/Voltage-gated potassium channel subunit Kv7.3
Organism Bos taurus
Uniprot IdP58126
Milk FractionWhey
Ref Sequence Id NP_776799.1
Aminoacid Length 866
Molecular Weight 95645
Fasta Sequence https://www.uniprot.org/uniprot/P58126.fasta
Gene Name KCNQ3
Gene Id 281884
Protein Existence Status reviewed

Secondary Information

Protein Function Associates with KCNQ2 or KCNQ5 to form a potassium channel
PTMs Phosphorylation,Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-51, 70-80, 488-496, 583-611, 660-662, 680-727, 763-768, 799-815, 832-866
DisProt Annotation
TM Helix Prediction 5 TMHs; (121-143), (155-177), (197-215), (264-282), (331-353)
Significance of PTMs ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation.
Additional Comments epilepsy is due to mutation of this gene.
Bibliography Rak SG, Drögemüller C, Leeb T, Quignon P, André C, Distl O. Assignment of the canine potassium voltage-gated channel, KQT-like subfamily, member 3 (KCNQ3) gene to CFA 13 by radiation hybrid mapping. Anim Genet. 2002 Aug;33(4):320-1. doi: 10.1046/j.1365-2052.2002.t01-6-00886.x. PMID: 12139519.