Search by BoMiProt ID - Bomi81


Primary Information

BoMiProt ID Bomi81
Protein Name Septin-11
Organism Bos taurus
Uniprot IDA2VE99
Milk FractionExosome
Ref Sequence ID NP_001075916.1
Aminoacid Length 425
Molecular Weight 48,992
FASTA Sequence Download
Gene Name SEPTIN11
Gene ID 535746
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function Septin filaments have a potential to form higher-order structures by self-organization; septin-based ring is necessary as the structural basis for cell wall deposition above the bud neck membrane; mammalian septins and related proteins are also implicated in exocytosis , apoptosis, leukemogenesis and carcinogenesis and neurodegeneration
Biochemical Properties Eukaryotic subfamily of guanine nucleotide binding proteins which form filamentous heteropolymer complexes; Septin filaments can assemble into bundles either autonomously or depending on actin bundles, using them as templates or scaffolds
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Linking IDs
Bibliography 1. Hsu, S. C., Hazuka, C. D., Roth, R., Foletti, D. L., Heuser, J., & Scheller, R. H. (1998). Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. Neuron, 20(6), 1111–1122. https://doi.org/10.1016/s0896-6273(00)80493-6.
2. Kinoshita, A., Kinoshita, M., Akiyama, H., Tomimoto, H., Akiguchi, I., Kumar, S., … Kimura, J. (1998). Identification of septins in neurofibrillary tangles in Alzheimer’s disease. The American Journal of Pathology, 153(5), 1551–1560. https://doi.org/10.1016/S0002-9440(10)65743-4.
3. DeMarini, D. J., Adams, A. E., Fares, H., De Virgilio, C., Valle, G., Chuang, J. S., & Pringle, J. R. (1997). A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall. The Journal of Cell Biology, 139(1), 75–93. https://doi.org/10.1083/jcb.139.1.75.