Primary Information |
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BoMiProt ID | Bomi8 |
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Protein Name | Plasminogen |
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Organism | Bos taurus |
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Uniprot ID | P06868 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_776376.1 |
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Aminoacid Length | 812 |
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Molecular Weight | 91216 |
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FASTA Sequence |
Download |
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Gene Name | PLG |
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Gene ID | 280897 |
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Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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Presence in other biological fluids/tissue/cells | blood, milk |
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Protein Function | Active form is plasmin; primary physiological
role in blood is to dissolve blood clots; In
bovine milk, plasmin is present mostly as plasminogen,
and the plasmin system is controlled by activators
and inhibitors; |
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Biochemical Properties | Plasmin catalyzes cleavages of Lys↓Xaa and Arg↓X bonds, with a specificity similar to that of trypsin; much less efficient enzyme than trypsin; esters and amides of arginine and lysine are cleaved with relative rates affected by the inherent susceptibility of the leaving group to hydrolysis; Most inhibitors of trypsin also inhibit plasmin |
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Significance in milk | associated with casein micelIes
in milk and degrades B-, cr,t- and a,z-caseins to y-caseins, proteose-peptones and
possibly I-casein. |
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PTMs | N-glycosylated; asparagine residue in position 289 |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P06868|PLMN_BOVIN Plasminogen OS=Bos taurus OX=9913 GN=PLG PE=1 SV=2
MLPASPKMEHKAVVFLLLLFLKSGLGDLLDDYVNTQGASLLSLSRKNLAG
RSVEDCAAKCEEETDFVCRAFQYHSKEQQCVVMAENSKNTPVFRMRDVIL
YEKRIYLLECKTGNGQTYRGTTAETKSGVTCQKWSATSPHVPKFSPEKFP
LAGLEENYCRNPDNDENGPWCYTTDPDKRYDYCDIPECEDKCMHCSGENY
EGKIAKTMSGRDCQAWDSQSPHAHGYIPSKFPNKNLKMNYCRNPDGEPRP
WCFTTDPQKRWEFCDIPRCTTPPPSSGPKYQCLKGTGKNYGGTVAVTESG
HTCQRWSEQTPHKHN*315RTPENFPCKNLEENYCRNPNGEKAPWCYTTNSEVR
WEYCTIPSCESSPLS*365TERMDVPVPPEQTPVPQDCYHGNGQSYRGTSSTTI
TGRKCQSWSSMTPHRHLKTPENYPNAGLTMNYCRNPDADKSPWCYTTDPR
VRWEFCNLKKCSETPEQVPAAPQAPGVENPPEADCMIGTGKSYRGKKATT
VAGVPCQEWAAQEPHQHSIFTPETNPQSGLERNYCRNPDGDVNGPWCYTM
NPRKPFDYCDVPQCESSFDCGKPKVEPKKCSGRIVGGCVSKPHSWPWQVS
LRRSSRHFCGGTLISPKWVLTAAHCLDNILALSFYKVILGAHNEKVREQS
VQEIPVSRLFREPSQADIALLKLSRPAIITKEVIPACLPPPNYMVAARTE
CYITGWGETQGTFGEGLLKEAHLPVIENKVCNRNEYLDGRVKPTELCAGH
LIGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSP
YVPWIEETMRRN
|
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Predicted Disorder Regions | 364-379,469-481 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | Deficiency in plasmin may lead to thrombosis; presence of plasmin may increase the risk of proliferative vitreoretinopathy |
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Bibliography | 1. Kaminogawa, S., & Yamauchi, K. (1972). Decomposition of β-casein by milk protease similarity of the decomposed products to temperature-sensitive and r-caseins. Agricultural and Biological Chemistry, 36(2), 255–260. https://doi.org/10.1080/00021369.1972.10860238. 2. Precetti, A. S., Oria, M. P., & Nielsen, S. S. (1997). Presence in bovine milk of two protease inhibitors of the plasmin system. Journal of Dairy Science, 80(8), 1490–1496. https://doi.org/10.3168/jds.S0022-0302(97)76077-6. 3. Reimerdes, E. H., & Herlitz, E. (1979). The formation of gamma-caseins during cooling of raw milk. The Journal of Dairy Research, 46(2), 219–221. https://doi.org/10.1017/s0022029900017076 |