Search by BoMiProt ID - Bomi7919


Primary Information

BoMiProt ID Bomi7919
Protein Name PHD finger protein 20-like protein 1
Organism Bos taurus
Uniprot IdA2VE56
Milk FractionWhey
Ref Sequence Id NP_001075901.1
Aminoacid Length 316
Molecular Weight 36160
Fasta Sequence https://www.uniprot.org/uniprot/A2VE56.fasta
Gene Name PHF20L1
Gene Id 511990
Protein Existence Status reviewed

Secondary Information

Protein Function histone methylation reader protein,regulation of transcription by RNA pol II.act on both methylated Lys-42 and Lys-117 to prevent SOX2 proteolysis.
Biochemical Properties  recognizes histone H3K4me2 via its PHD finger, and the H3K4me2-binding function of the PHD finger is essential for PHF20-dependent histone acetylation.Also contain WD40 repeats, CW domains, PWWP domains, and the royal superfamily, including proteins with chromodomains, TUDOR domains, and malignant brain tumor (MBT) repeats.TUDOR domain–containing proteins (TDRDs) have the potential to recognize histone methylation.
PTMs Isopeptide bond, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-11, 134-148, 154-171, 178-316
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments  loss of either LSD1 or PHF20L1 destabilizes SOX2 protein and impairs the self-renewal and pluripotency of mouse ES cells
Bibliography 1.Hou Y, Liu W, Yi X, Yang Y, Su D, Huang W, Yu H, Teng X, Yang Y, Feng W, Zhang T, Gao J, Zhang K, Qiu R, Wang Y. PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis. Sci Adv. 2020 Apr 15;6(16):eaaz0356. doi: 10.1126/sciadv.aaz0356. PMID: 32494608; PMCID: PMC7159910. 2.Zhang C, Leng F, Saxena L, Hoang N, Yu J, Alejo S, Lee L, Qi D, Lu F, Sun H, Zhang H. Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase. J Biol Chem. 2019 Jan 11;294(2):476-489. doi: 10.1074/jbc.RA118.005336. Epub 2018 Nov 15. PMID: 30442713; PMCID: PMC6333883.