Search by BoMiProt ID - Bomi7908


Primary Information

BoMiProt ID Bomi7908
Protein Name PGC-1 and ERR-induced regulator in muscle protein 1/PPARGC1 and ESRR-induced regulator in muscle 1/Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1
Organism Bos taurus
Uniprot IdA5D7L8
Milk FractionWhey
Ref Sequence Id NP_001091517.1
Aminoacid Length 901
Molecular Weight 94210
Fasta Sequence https://www.uniprot.org/uniprot/A5D7L8.fasta
Gene Name PERM1
Gene Id 520080
Protein Existence Status reviewed

Secondary Information

Protein Function Perm1 interacts with CaMKII and activates the CaMKII-MEF2 pathway.In endurance training, Perm1 impacts muscle oxidative metabolism pathway responses.
Significance in milk skeletal muscle development
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions (1-28), (47-67), (186-196), (252-274), (291-294), (319-485), (576-582), (684-688), (709-729), (798-806), (894-901)
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Perm1 is important for skeletal muscle adaptation to endurance training
Bibliography Cho Y, Tachibana S, Hazen BC, Moresco JJ, Yates JR 3rd, Kok B, Saez E, Ross RS, Russell AP, Kralli A. Perm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training. Mol Metab. 2019 May;23:88-97. doi: 10.1016/j.molmet.2019.02.009. Epub 2019 Feb 27. PMID: 30862473; PMCID: PMC6480336.