Search by BoMiProt ID - Bomi7907


Primary Information

BoMiProt ID Bomi7907
Protein Name Peroxisomal N(1)-acetyl-spermine/spermidine oxidase/Polyamine oxidase
Organism Bos taurus
Uniprot IdQ865R1
Milk FractionWhey
Ref Sequence Id NP_001013620.2
Aminoacid Length 512
Molecular Weight 56325
Fasta Sequence https://www.uniprot.org/uniprot/Q865R1.fasta
Gene Name PAOX/PAO
Gene Id 282639
Protein Existence Status reviewed

Secondary Information

Protein Function Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed β H-Crystallins Polymerization in Calcium-Induced Experimental Cataract
Biochemical Properties The catabolism of spermine to spermidine utilizes either the one-step enzymatic reaction of spermine oxidase (SMO) or the two-step process of spermidine/spermine N (1)-acetyltransferase (SSAT) coupled with the peroxisomal enzyme N (1)-acetylpolyamine oxidase.
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs The acetylated polyamines have two potential fates. First, acetylated polyamines can be exported from the cell. Second, acetylated spermidine and spermine are substrates for the FADdependent, peroxisomal APAO (
Additional Comments  The increase of endogenous SPD in the cultured rabbit lens showed the activation of a flavin adenine dinucleotide (FAD)-dependent polyamine oxidases
Bibliography 1.Battaglia V, DeStefano Shields C, Murray-Stewart T, Casero RA Jr. Polyamine catabolism in carcinogenesis: potential targets for chemotherapy and chemoprevention. Amino Acids. 2014 Mar;46(3):511-9. doi: 10.1007/s00726-013-1529-6. Epub 2013 Jun 15. PMID: 23771789; PMCID: PMC3795954. 2.Mischiati C, Feriotto G, Tabolacci C, Domenici F, Melino S, Borromeo I, Forni C, De Martino A, Beninati S. Polyamine Oxidase Is Involved in Spermidine Reduction of Transglutaminase Type 2-Catalyzed βH-Crystallins Polymerization in Calcium-Induced Experimental Cataract. Int J Mol Sci. 2020 Jul 30;21(15):5427. doi: 10.3390/ijms21155427. PMID: 32751462; PMCID: PMC7432200.