Search by BoMiProt ID - Bomi7903


Primary Information

BoMiProt ID Bomi7903
Protein Name Peroxisomal carnitine O-octanoyltransferase
Organism Bos taurus
Uniprot IdO19094
Milk FractionWhey
Ref Sequence Id NP_803460.1
Aminoacid Length 612
Molecular Weight 70263
Fasta Sequence https://www.uniprot.org/uniprot/O19094.fasta
Gene Name CROT/COT
Gene Id 281092
Protein Existence Status reviewed

Secondary Information

Protein Function Participate in beta-oxidation of fatty acids.
Biochemical Properties transesterifies medium- and long-chain fatty acyl chains and belongs to a carnitine acyltransferase family that catalyzes a reversible reaction of L-carnitine + acyl-CoA ⇄ acyl-L-carnitine + CoASH.
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Okui T, Iwashita M, Rogers MA, Halu A, Atkins SK, Kuraoka S, Abdelhamid I, Higashi H, Ramsaroop A, Aikawa M, Singh SA, Aikawa E. CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction. Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):755-768. doi: 10.1161/ATVBAHA.120.315007. Epub 2020 Dec 24. PMID: 33356393; PMCID: PMC8105275.