Search by BoMiProt ID - Bomi7879


Primary Information

BoMiProt ID Bomi7879
Protein Name Peptidyl-prolyl cis-trans isomerase F, mitochondrial(PPIase F)/Cyclophilin D/Cyclophilin F/Rotamase F
Organism Bos taurus
Uniprot IdP30404
Milk FractionWhey
Ref Sequence Id NP_001001597.1
Aminoacid Length 208
Molecular Weight 22019
Fasta Sequence https://www.uniprot.org/uniprot/P30404.fasta
Gene Name PPIF/CYP3
Gene Id 414346
Protein Existence Status reviewed

Secondary Information

Protein Function Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils
Biochemical Properties Cyclophilin D belongs to the cyclophilin family, has peptidyl-prolyl cis-trans isomerase activity, and is uniquely located in the mitochondrial matrix.
PTMs Acetylation at Lys
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 25-45, 114-120
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments The genetic ablation of cyclophilin D or its inhibition by cyclosporin A results in accelerated proton pumping by ATP hydrolysis, opposing a further decrease in membrane potential and promoting high matrix phosphate levels.
Bibliography 1.Chinopoulos C, Adam-Vizi V. Modulation of the mitochondrial permeability transition by cyclophilin D: moving closer to F(0)-F(1) ATP synthase? Mitochondrion. 2012 Jan;12(1):41-5. doi: 10.1016/j.mito.2011.04.007. Epub 2011 May 8. PMID: 21586346. 2.Zhu X, Hogan SP, Molkentin JD, Zimmermann N. Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 15;310(8):G609-17. doi: 10.1152/ajpgi.00389.2015. Epub 2016 Feb 18. PMID: 26893161; PMCID: PMC4836130.