Primary Information |
|---|
| BoMiProt ID | Bomi7873 |
|---|
| Protein Name | Peptidase inhibitor 16(PI-16)/CD_antigen: CD364 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot Id | Q58D34 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence Id | NP_001019658.1 |
|---|
| Aminoacid Length | 464 |
|---|
| Molecular Weight | 49327 |
|---|
| Fasta Sequence | https://www.uniprot.org/uniprot/Q58D34.fasta |
|---|
| Gene Name | PI16 |
|---|
| Gene Id | 507058 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | is a membrane-tethered regulator of chemerin processing in the myocardium.A member of the CAP family of proteins which we found to be highly upregulated in cardiac disease. |
|---|
| PTMs | glycosylation |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q58D34|PI16_BOVIN Peptidase inhibitor 16 OS=Bos taurus OX=9913 GN=PI16 PE=2 SV=1
MHGSGSLLACLLPPLLLLGAAPGPAGALSEEEKHVMVELHNLYRTQVSPPATNMLQMRWD
EELAAFAKAYAQQCVWGHNKERGRRGENLFAITGEGLDVPLAMEEWHHERLEHYN*114SAISC
AAGQMCGHYTQVVWAKTERIGCGSHFCEKLQGVEETNIHLLVCNYEPPGNVKGQRPYQEG
TPCSQCPLGYHCKNSLCEPIRGPEEAQDLSSLVPEAPSSLATEASSSRREGIDSSLATEP
PPFLVTEVSGSLATKVLSSVETKAPSSLVTEDSPSMATKTPLSLATKVPSVLATHSLLSL
DKRPATLLPKSTHDPIPKSADKEASSTRMPSRIPESSLHPKISLMGTREPLPLSQEEGEA
EAELAHCSEILASVFPAQEKPGELQTTLKHKGHSSSKSLSNSPSASATANAVGGRTLALQ
SSLPDAEGPGKHGFRSGSNASPGHVGGLLLGLLLLLPLVLAGIF
|
|---|
| Predicted Disorder Regions | 2 disordered segments; (214-412), (421-441) |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | 1TMH; (445-463) |
|---|
| Significance of PTMs | N glycosylated |
|---|
| Bibliography | Regn M, Laggerbauer B, Jentzsch C, Ramanujam D, Ahles A, Sichler S, Calzada-Wack J, Koenen RR, Braun A, Nieswandt B, Engelhardt S. Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium. J Mol Cell Cardiol. 2016 Oct;99:57-64. doi: 10.1016/j.yjmcc.2016.08.010. Epub 2016 Aug 15. PMID: 27539859. |
|---|
