Search by BoMiProt ID - Bomi7793


Primary Information

BoMiProt ID Bomi7793
Protein Name p21-activated protein kinase-interacting protein 1/PAK1-interacting protein 1
Organism Bos taurus
Uniprot IdQ5EA99
Milk FractionWhey
Ref Sequence Id NP_001014852.1
Aminoacid Length 392
Molecular Weight 44049
Fasta Sequence https://www.uniprot.org/uniprot/Q5EA99.fasta
Gene Name PAK1IP1
Gene Id 505125
Protein Existence Status reviewed

Secondary Information

Protein Function p21-activated kinase 1 (PAK1) is a serine/threonine kinase that direct cell motility, cytoskeletal remodelling, and has been shown to function as a downstream regulator for various cancer signalling cascades that promote cell proliferation, apoptosis deregulation and hasten mitotic abnormalities, resulting in tumor formation and progression.
Biochemical Properties p21-activated kinase 1 signalling is crucial for activation of the Ras/RAF/MEK/ERK, PI3K/Akt/mTOR and Wnt signalling cascades which regulate cell survival, cell cycle progression, differentiation, and proliferation.
PTMs Phosphorylation at Serine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 307-392
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments GIT1/βPIX signaling proteins with PAK1 kinase represent a novel regulatory mechanism of microtubule nucleation in interphase cells.
Bibliography 1.Kanumuri R, Saravanan R, Pavithra V, Sundaram S, Rayala SK, Venkatraman G. Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers. Gene. 2020 Nov 15;760:144991. doi: 10.1016/j.gene.2020.144991. Epub 2020 Jul 25. PMID: 32717309. 2.Černohorská M, Sulimenko V, Hájková Z, Sulimenko T, Sládková V, Vinopal S, Dráberová E, Dráber P. GIT1/βPIX signaling proteins and PAK1 kinase regulate microtubule nucleation. Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1282-97. doi: 10.1016/j.bbamcr.2016.03.016. Epub 2016 Mar 22. Erratum in: Biochim Biophys Acta. 2017 Apr;1864(4):747. PMID: 27012601.