Primary Information |
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| BoMiProt ID | Bomi7793 |
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| Protein Name | p21-activated protein kinase-interacting protein 1/PAK1-interacting protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q5EA99 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001014852.1 |
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| Aminoacid Length | 392 |
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| Molecular Weight | 44049 |
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| FASTA Sequence |
Download |
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| Gene Name | PAK1IP1 |
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| Gene ID | 505125 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | p21-activated kinase 1 (PAK1) is a serine/threonine kinase that direct cell motility, cytoskeletal remodelling, and has been shown to function as a downstream regulator for various cancer signalling cascades that promote cell proliferation, apoptosis deregulation and hasten mitotic abnormalities, resulting in tumor formation and progression. |
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| Biochemical Properties | p21-activated kinase 1 signalling is crucial for activation of the Ras/RAF/MEK/ERK, PI3K/Akt/mTOR and Wnt signalling cascades which regulate cell survival, cell cycle progression, differentiation, and proliferation. |
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| PTMs | Phosphorylation at Serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 307-392 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | GIT1/βPIX signaling proteins with PAK1 kinase represent a novel regulatory mechanism of microtubule nucleation in interphase cells. |
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| Bibliography | 1.Kanumuri R, Saravanan R, Pavithra V, Sundaram S, Rayala SK, Venkatraman G. Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers. Gene. 2020 Nov 15;760:144991. doi: 10.1016/j.gene.2020.144991. Epub 2020 Jul 25. PMID: 32717309. 2.Černohorská M, Sulimenko V, Hájková Z, Sulimenko T, Sládková V, Vinopal S, Dráberová E, Dráber P. GIT1/βPIX signaling proteins and PAK1 kinase regulate microtubule nucleation. Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1282-97. doi: 10.1016/j.bbamcr.2016.03.016. Epub 2016 Mar 22. Erratum in: Biochim Biophys Acta. 2017 Apr;1864(4):747. PMID: 27012601. |
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