Search by BoMiProt ID - Bomi7792


Primary Information

BoMiProt ID Bomi7792
Protein Name Oxysterols receptor LXR-alpha/Liver X receptor alpha/Nuclear receptor subfamily 1 group H member 3
Organism Bos taurus
Uniprot IdQ5E9B6
Milk FractionWhey
Ref Sequence Id NP_001014861.1
Aminoacid Length 447
Molecular Weight 50529
Fasta Sequence https://www.uniprot.org/uniprot/Q5E9B6.fasta
Gene Name NR1H3/LXRA
Gene Id 507176
Protein Existence Status reviewed

Secondary Information

Protein Function Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the transcriptional control of lipid metabolism.  LXRs also regulate fatty acid metabolism by controlling the lipogenic transcription factor sterol regulatory element-binding protein 1c .
Biochemical Properties LXR activation preferentially drives the incorporation of polyunsaturated fatty acids into phospholipids by inducing transcription of the remodelling enzyme lysophosphatidylcholine acyltransferase 3.
Significance in milk Liver x receptors (LXR) and retinoid x receptors (RXR) regulate lipogenesis and are known to bind polyunsaturated FA and LXR agonist increases lipid synthesis in mammary epithelial cell culture.
PTMs Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-96, 172-177, 188-205, 235-239
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments The ability of the LXR pathway to couple cellular sterol levels with the saturation of fatty acids in membrane phospholipids has implications for several physiological processes, including lipoprotein production, dietary lipid absorption and intestinal stem cell proliferation.
Bibliography 1.Wang B, Tontonoz P. Liver X receptors in lipid signalling and membrane homeostasis. Nat Rev Endocrinol. 2018 Aug;14(8):452-463. doi: 10.1038/s41574-018-0037-x. PMID: 29904174; PMCID: PMC6433546. 2.Harvatine, K. J., Boisclair, Y. R., & Bauman, D. E. (2014). Liver x receptors stimulate lipogenesis in bovine mammary epithelial cell culture but do not appear to be involved in diet-induced milk fat depression in cows. Physiological reports, 2(3), e00266. https://doi.org/10.1002/phy2.266