Primary Information |
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| BoMiProt ID | Bomi7792 |
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| Protein Name | Oxysterols receptor LXR-alpha/Liver X receptor alpha/Nuclear receptor subfamily 1 group H member 3 |
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| Organism | Bos taurus |
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| Uniprot ID | Q5E9B6 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001014861.1 |
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| Aminoacid Length | 447 |
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| Molecular Weight | 50529 |
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| FASTA Sequence |
Download |
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| Gene Name | NR1H3/LXRA |
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| Gene ID | 507176 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the transcriptional control of lipid metabolism. LXRs also regulate fatty acid metabolism by controlling the lipogenic transcription factor sterol regulatory element-binding protein 1c . |
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| Biochemical Properties | LXR activation preferentially drives the incorporation of polyunsaturated fatty acids into phospholipids by inducing transcription of the remodelling enzyme lysophosphatidylcholine acyltransferase 3. |
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| Significance in milk | Liver x receptors (LXR) and retinoid x receptors (RXR) regulate lipogenesis and are known to bind polyunsaturated FA and LXR agonist increases lipid synthesis in mammary epithelial cell culture. |
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| PTMs | Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-96, 172-177, 188-205, 235-239 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | The ability of the LXR pathway to couple cellular sterol levels with the saturation of fatty acids in membrane phospholipids has implications for several physiological processes, including lipoprotein production, dietary lipid absorption and intestinal stem cell proliferation. |
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| Bibliography | 1.Wang B, Tontonoz P. Liver X receptors in lipid signalling and membrane homeostasis. Nat Rev Endocrinol. 2018 Aug;14(8):452-463. doi: 10.1038/s41574-018-0037-x. PMID: 29904174; PMCID: PMC6433546. 2.Harvatine, K. J., Boisclair, Y. R., & Bauman, D. E. (2014). Liver x receptors stimulate lipogenesis in bovine mammary epithelial cell culture but do not appear to be involved in diet-induced milk fat depression in cows. Physiological reports, 2(3), e00266. https://doi.org/10.1002/phy2.266 |
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