Primary Information |
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| BoMiProt ID | Bomi7703 |
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| Protein Name | Nucleoporin SEH1/GATOR complex protein SEH1/Nup107-160 subcomplex subunit SEH1 |
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| Organism | Bos taurus |
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| Uniprot ID | A7YY75 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001096559.1 |
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| Aminoacid Length | 360 |
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| Molecular Weight | 39641 |
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| FASTA Sequence |
Download |
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| Gene Name | SEH1L |
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| Gene ID | 506509 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Component of the Nup107-160 complex of the nuclear pore complex (NPC).essential for the association of both the GATOR2 complex and nucleoporin Nup153 with mitotic chromosomes.required for efficient localisation of the chromosomal passenger complex (CPC). |
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| PTMs | phosphorylation on Ser and Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7YY75|SEH1_BOVIN Nucleoporin SEH1 OS=Bos taurus OX=9913 GN=SEH1L PE=2 SV=1
MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGEWHCTASWKTHSGSV
WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK
FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHAP
MIAVGSDDSS*190PNAMAKVQIFEYNENTRKYAKAETLLTVTDPVHDIAFAPNLGRSFHILAI
ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG
CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGNSNPSVGSNIPSLQNSLNGSSAGRKHS
|
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| Predicted Disorder Regions | 330-360 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | O-GlcNAcylation and ubiquitination to regulate Nup turnover. phosphorylation and ubiquitination play destructive roles in disassembling NPCs and degrading Nups, respectively. |
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| Bibliography | Platani M, Samejima I, Samejima K, Kanemaki MT, Earnshaw WC. Seh1 targets GATOR2 and Nup153 to mitotic chromosomes. J Cell Sci. 2018 May 1;131(9):jcs213140. doi: 10.1242/jcs.213140. PMID: 29618633; PMCID: PMC5992584. |
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