Primary Information |
|---|
| BoMiProt ID | Bomi7683 |
|---|
| Protein Name | Nucleolar protein 12 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot Id | Q2KIV0 |
|---|
| Milk Fraction | Whey |
|---|
| Aminoacid Length | 213 |
|---|
| Molecular Weight | 24707 |
|---|
| Fasta Sequence | https://www.uniprot.org/uniprot/Q2KIV0.fasta |
|---|
| Gene Name | NOL12 |
|---|
| Gene Id | 615252 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | May bind to 28S rRNA.NOL12 repression induces specific changes in nucleolar morphology, with increased nucleolar area but reduced nucleolar number, along with nucleolar accumulation and increased levels of fibrillarin and nucleolin.NOL12 repression leads to stabilization and activation of p53 in an RPL11-dependent manner, which arrests cells at G2 phase and ultimately leads to senescence.The yeast NOL12 homologue Rrp17 was shown to function as a 5′-to-3′ RNA exonuclease for processing of the internal transcribed spacer 1 (ITS1) region of pre-rRNA during ribosome biogenesis.NOL12 regulates nucleolar structure and the protein levels of fibrillarin and nucleolin. |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
|---|
| Predicted Disorder Regions | (1-213) |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Bibliography | Pinho M, Macedo JC, Logarinho E, Pereira PS. NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging. Mol Cell Biol. 2019 May 28;39(12):e00099-19. doi: 10.1128/MCB.00099-19. PMID: 30988155; PMCID: PMC6549468. |
|---|
