Search by BoMiProt ID - Bomi7535


Primary Information

BoMiProt ID Bomi7535
Protein Name N-myc-interactor/N-myc and STAT interactor
Organism Bos taurus
Uniprot IdQ3ZCL3
Milk FractionWhey,exosome
Ref Sequence Id NP_001030270.1
Aminoacid Length 309
Molecular Weight 35395
Fasta Sequence https://www.uniprot.org/uniprot/Q3ZCL3.fasta
Gene Name NMI
Gene Id 511280
Protein Existence Status Reviewed

Secondary Information

Protein Function N-myc interactor (NMI), a member of the oncogene Myc family, has been reported to be closely related to the development of cancer.
PTMs Isopeptide bond formation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-90, 307-309
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Ubiquitination at 'Lys-63' by TRIM21 promotes interaction with IFI35 and inhibits virus-triggered type I IFN-beta production.
Additional Comments  the downregulation of NMI plays an important role in the progression of cervical cancer, and may served as a novel therapeutic target for cervical cancer.
Bibliography 1.Wu S, Li X, Chai H, Feng L, Li W, Li H. Downregulation of N-myc Interactor Promotes Cervical Cancer Cells Growth by Activating Stat3 Signaling. Cell Biochem Biophys. 2021 Mar;79(1):103-111. doi: 10.1007/s12013-020-00943-0. Epub 2020 Oct 27. PMID: 33106998.