Search by BoMiProt ID - Bomi7464


Primary Information

BoMiProt ID Bomi7464
Protein Name Neuropeptide Y receptor type 2/NPY-Y2 receptor/NPY2-R/Y2 receptor
Organism Bos taurus
Uniprot IdP79113
Milk FractionWhey
Ref Sequence Id NP_776826.1
Aminoacid Length 384
Molecular Weight 42943
Fasta Sequence https://www.uniprot.org/uniprot/P79113.fasta
Gene Name NPY2R
Gene Id 281943
Protein Existence Status reviewed

Secondary Information

Protein Function Receptor for neuropeptide Y and peptide YY,hypothalamic regulator of feeding behavior,metabolism, and energy homeostasis in both rodents and humans.neuropeptide Y is known to regulate bone homeostasis.
PTMs Disulfide bond formation, Glycosylation, Lipidation, Palmitoylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-44, 262-267, 371-384
DisProt Annotation
TM Helix Prediction 7TMHs; (55-77),(90-112),(131-149),(167-189),(220-242),(272-294) & (309-331)
Additional Comments knock-out mice for the gene neuropeptide Y 2 receptor, NPY2R, exhibit hyperphagia and excessive weight gain
Bibliography Maron JL, Johnson KL, Dietz JA, Chen ML, Bianchi DW. Neuropeptide Y2 receptor (NPY2R) expression in saliva predicts feeding immaturity in the premature neonate. PLoS One. 2012;7(5):e37870. doi: 10.1371/journal.pone.0037870. Epub 2012 May 21. PMID: 22629465; PMCID: PMC3357390.