Search by BoMiProt ID - Bomi7445


Primary Information

BoMiProt ID Bomi7445
Protein Name Neurogranin/B-50 immunoreactive C-kinase substrate/BICKS/p17
Organism Bos taurus
Uniprot IdP35722
Milk FractionWhey
Ref Sequence Id NP_001106784.1
Aminoacid Length 78
Molecular Weight 7549
Fasta Sequence https://www.uniprot.org/uniprot/P35722.fasta
Gene Name NRGN
Gene Id 616955
Protein Existence Status reviewed

Secondary Information

Protein Function Neurogranin (Ng) is a neural-specific postsynaptic protein that is highly enriched in dendrites and role in synaptic activity.promotes synaptogenesis.
PTMs Acetylation, Citrullination, Methylation, Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P35722|NEUG_BOVIN Neurogranin OS=Bos taurus OX=9913 GN=NRGN PE=1 SV=3 MDCCTESACSKPDDDILDIPLDDPGANAAAAKIQAS*36FRGHMARKKIKSGERGRKGPGPGG PGGAGGARGGAGGGPSGD
Predicted Disorder Regions 1 disordered segment; (1-78)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions
Bibliography Xiang Y, Xin J, Le W, Yang Y. Neurogranin: A Potential Biomarker of Neurological and Mental Diseases. Front Aging Neurosci. 2020 Oct 6;12:584743. doi: 10.3389/fnagi.2020.584743. PMID: 33132903; PMCID: PMC7573493.