Primary Information |
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| BoMiProt ID | Bomi7396 |
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| Protein Name | NEDD8/Neddylin/Ubiquitin-like protein Nedd8 |
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| Organism | Bos taurus |
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| Uniprot ID | P61282 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_777189.1 |
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| Aminoacid Length | 81 |
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| Molecular Weight | 9072 |
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| FASTA Sequence |
Download |
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| Gene Name | NEDD8 |
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| Gene ID | 286796 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | The ubiquitin-related protein NEDD8 is conjugated and deconjugated to and from proteins in processes related to ubiquitin conjugation and deconjugation. |
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| Biochemical Properties | NEDD8 is nearly encircled by interactions, binding its linked CUL1 WHB domain in an “activation module”, and positioning a “catalytic module” relative to the substrate scaffolding module to juxtapose the active site and substrate. |
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| PTMs | N6-Acetylation at Lys, Isopeptide bond formation,Cleavage by UCHL3 or SENP8 |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Cleavage of precursor form by UCHL3 or SENP8 is necessary for function. |
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| Additional Comments | NEDD8 Overexpression Results in Neddylation of Ubiquitin Substrates by the Ubiquitin Pathway |
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| Bibliography | 1.Schwechheimer C. NEDD8-its role in the regulation of Cullin-RING ligases. Curr Opin Plant Biol. 2018 Oct;45(Pt A):112-119. doi: 10.1016/j.pbi.2018.05.017. Epub 2018 Jun 15. PMID: 29909289. 2.Baek K, Krist DT, Prabu JR, Hill S, Klügel M, Neumaier LM, von Gronau S, Kleiger G, Schulman BA. NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly. Nature. 2020 Feb;578(7795):461-466. doi: 10.1038/s41586-020-2000-y. Epub 2020 Feb 12. PMID: 32051583; PMCID: PMC7050210. 3.Roland Hjerpe; Yann Thomas; Thimo Kurz (2012). NEDD8 Overexpression Results in Neddylation of Ubiquitin Substrates by the Ubiquitin Pathway. , 421(1), –. doi:10.1016/j.jmb.2012.05.013. |
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