Search by BoMiProt ID - Bomi7370


Primary Information

BoMiProt ID Bomi7370
Protein Name NADH-ubiquinone oxidoreductase chain 5/NADH dehydrogenase subunit 5
Organism Bos taurus
Uniprot IDP03920
Milk FractionWhey,MFGM
Aminoacid Length 606
Molecular Weight 68286
FASTA Sequence Download
Gene Name MT-ND5/NADH5/ ND5
Protein Existence Status reviewed

Secondary Information

Protein Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I).Participate in oxidative phosphorylation.
Biochemical Properties couples the oxidation of NADH for the reduction of ubiquinone with the generation of a proton gradient that can be used for the synthesis of ATP.
PTMs Formylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
SCOP Class : All alpha proteins
Fold : Antiporter subunits half-channel-like
Superfamily : Antiporter subunits half-channel-like
Family : n/a
Domain Name : 5LC5 L:113-268

Class : All alpha proteins
Fold : Antiporter subunits half-channel-like
Superfamily : Antiporter subunits half-channel-like
Family : ND5 antiporter-like subunits
Domain Name : 5LC5 L:2-605

CATH Matched CATH superfamily
n/a
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 14TMHs; (9-27), (34-56), (85-107), (120-138), (142-160), (172-190), (243-265), (272-294), (313-335), (366-388), (407-429), (450-468), (480-502), (586-604)
PDB ID 5LC5,5LDW,5LDX,5O31,
Additional Comments Leber's hereditary optic neuropathy is the result of this gene mutation.MT-ND5 gene variation was significantly associated with brain mitochondrial respiratory function in Tibet chicken embryos under hypoxia. This identifies MT-ND5 as a candidate gene for adaptation to hypoxia (or high hatchability under hypoxia)
Bibliography 1.Bao HG, Zhao CJ, Li JY, Wu Ch. Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos. Anim Genet. 2007 Oct;38(5):514-6. doi: 10.1111/j.1365-2052.2007.01622.x. Epub 2007 Jul 5. PMID: 17614984. 2.Seong MW, Choi J, Park SS, Kim JY, Hwang JM. Novel MT-ND5 gene mutation identified in Leber's hereditary optic neuropathy patient using mitochondrial genome sequencing. J Neurol Sci. 2017 Apr 15;375:301-303. doi: 10.1016/j.jns.2017.01.064. Epub 2017 Jan 24. PMID: 28320155.