Primary Information | |
---|---|
BoMiProt ID | Bomi7368 |
Protein Name | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial/Complex I-75kD/CI-75kD |
Organism | Bos taurus |
Uniprot ID | P15690 |
Milk Fraction | Whey,MFGM |
Ref Sequence ID | NP_777245.1 |
Aminoacid Length | 727 |
Molecular Weight | 79442 |
FASTA Sequence | Download |
Gene Name | NDUFS1 |
Gene ID | 288380 |
Protein Existence Status | reviewed |
Secondary Information | |
Protein Function | This is important for energy metabolism because it is the initial enzyme of the mitochondrial respiratory chain. Reduction of the 75kDa subunit may lead to the impairment of energy metabolism and result in neuronal cell death (apoptosis), a hallmark of both neurodegenerative disorders Down syndrome (DS) and Alzheimer's disease (AD). |
PTMs | Acetylation |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | NA |
CATH | Matched CATH superfamily n/a |
Predicted Disorder Regions | NA |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
PDB ID | 5LC5,5LDW,5LDX,5O31, |
Additional Comments | NADH: ubiquinone oxidoreductase (complex I) appears to consist of 41 subunits including 7 subunits encoded in the mitochondrial DNA (mtDNA) and 34 subunits encoded in nuclear DNA (nDNA) |
Bibliography | Kim SH, Vlkolinsky R, Cairns N, Fountoulakis M, Lubec G. The reduction of NADH ubiquinone oxidoreductase 24- and 75-kDa subunits in brains of patients with Down syndrome and Alzheimer's disease. Life Sci. 2001 May 4;68(24):2741-50. doi: 10.1016/s0024-3205(01)01074-8. PMID: 11400916. |