Primary Information |
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| BoMiProt ID | Bomi7324 |
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| Protein Name | Na(+)/H(+) exchange regulatory cofactor NHE-RF3/Na(+)/H(+) exchanger regulatory factor 3/PDZ domain-containing protein 1/Sodium-hydrogen exchanger regulatory factor 3 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3T0X8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029783.1 |
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| Aminoacid Length | 520 |
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| Molecular Weight | 57175 |
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| FASTA Sequence |
Download |
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| Gene Name | PDZK1/NHERF3/PDZD1 |
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| Gene ID | 534439 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | NHE-RF mediates protein kinase A regulation of Na(+)-H+ exchanger NHE3 to which it is thought to bind via one of its two PDZ domains. |
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| Biochemical Properties | The carboxyl-terminal region of NHE-RF, downstream of the PDZ domains, interacts with the amino-terminal protein 4.1 domain-containing segment of merlin |
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| PTMs | Phosphorylation on Ser and Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3T0X8|NHRF3_BOVIN Na(+)/H(+) exchange regulatory cofactor NHE-RF3 OS=Bos taurus OX=9913 GN=PDZK1 PE=2 SV=1
MASTFNPRECKLTKQEGNSYGFFLRIEKDTDGHLVRVIEKGSPAEKAGLQDGDRVLRING
VFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAMKKQVDLKALGQS*108QEPSLNDKKAPS
VMNGGAQMWMQPRLCYLVKEGGSYGFS*147LKTVQGKNGVYMTDIKPQGVAMKAGVLADDHLI
EVNGENVEDAS*191HEEVVEKVKKSGSRVTFLLVDKETDKHHSEQKIKVKRETASLKLLPCQP
RVVEMKKGS*249NGYGFYLRESPEQKGQIIKDIDPKSPAEKAGLKNNDLVVAVNGKSVESLDH
DSVVEMIRKGGDQTSLLVVDKETDNIYKLAGFS*333PFFYYQSQELPNGS*347VKEVPAPTPAPLE
VSSPETTEEVGDHKPKLCRLARGEDGYGFHLNAVRGQPGSFVKEVQKGGPADLAGLEDED
VIIEVNGVNMLDESYEKVVDRIQSSGKTVT*450LLVCGKKAYDYFQAKKIPIVSSMADPLDDD
PDPDEGRLEGS*491EQNSHMAEERERAHSTAS*509HS*511S*512S*513NS*515EDTEM
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| Predicted Disorder Regions | 220-228, 346-354, 462-465, 485-520 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Murthy A, Gonzalez-Agosti C, Cordero E, Pinney D, Candia C, Solomon F, Gusella J, Ramesh V. NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. J Biol Chem. 1998 Jan 16;273(3):1273-6. doi: 10.1074/jbc.273.3.1273. PMID: 9430655. |
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